Gasping syndrome

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]

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Overview

Gasping syndrome is a life-threatening condition in neonates characterized by multi-system failure and death following the administration of benzyl alcohol, in the form of bacteriostatic sodium chloride and bacteriostatic water.

Symptoms

• Gradual neurologic deterioration
• Severe metabolic acidosis
• Sudden onset of gasping respiration
• Hematologic abnormalities
• Skin changes
• Hepatic failure
• Renal failure
• Hypotension
• Cardiovascular collapse

Drugs containing benzyl alcohol

• Lincomycin Hydrochloride
• Mecasermin
• Sargramostim