Gadoteric acid

Gadoteric acid

Gene therapy
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	V08CA02 (WHO)
Physiological data
Legal status
Pharmacokinetic data
Identifiers
IUPAC name gadolinium(+3) cation; 2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetate
CAS Number	72573-82-1 Y
PubChem Template:Abbreviation	3085828
UNII	QVF9Y6955W
KEGG	D08007 Y
Chemical and physical data
Formula	C16H25GdN4O8
Molar mass	558.64 g/mol
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Gadoteric acid (trade names Artirem, Dotarem) is a macrocycle-structured gadolinium-based MRI contrast agent. It consists of the organic acid DOTA as a chelating agent, and gadolinium (Gd³⁺), and is used in form of the meglumine salt. The drug is approved and used in a number of countries worldwide. It is used to assist imaging of blood vessels and of inflamed or diseased tissue where the blood vessels become 'leaky'. It is often used when viewing intracranial lesions with abnormal vascularity or abnormalities in the blood–brain barrier. Its paramagnetic property reduces the T1 relaxation time (and to some extent the T2 and T2* relaxation times) in NMR, which is the source of its clinical utility.