Glycosylphosphatidylinositol anchor attachment 1 protein is a protein that in humans is encoded by the GPAA1gene.[1][2]
Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains.[2]
↑Hiroi Y, Komuro I, Matsushita I, Aburatani H, Hosoda T, Nakahori Y, Medof ME, Yazaki Y (January 1999). "Assignment of the human GPAA1 gene, which encodes a product required for the attachment of glycosylphosphatidylinositols to proteins, at 8q24". Genomics. 54 (2): 354–5. doi:10.1006/geno.1998.5490. PMID9828142.
↑ 4.04.1Vainauskas, Saulius; Maeda Yusuke; Kurniawan Henry; Kinoshita Taroh; Menon Anant K (August 2002). "Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex". J. Biol. Chem. United States. 277 (34): 30535–42. doi:10.1074/jbc.M205402200. ISSN0021-9258. PMID12052837.
Hiroi Y, Komuro I, Chen R, et al. (1998). "Molecular cloning of human homolog of yeast GAA1 which is required for attachment of glycosylphosphatidylinositols to proteins". FEBS Lett. 421 (3): 252–8. doi:10.1016/S0014-5793(97)01576-7. PMID9468317.
Inoue N, Ohishi K, Endo Y, et al. (1999). "Human and mouse GPAA1 (Glycosylphosphatidylinositol anchor attachment 1) genes: genomic structures, chromosome loci and the presence of a minor class intron". Cytogenet. Cell Genet. 84 (3–4): 199–205. doi:10.1159/000015258. PMID10393431.
Vainauskas S, Maeda Y, Kurniawan H, et al. (2002). "Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex". J. Biol. Chem. 277 (34): 30535–42. doi:10.1074/jbc.M205402200. PMID12052837.
Ohishi K, Nagamune K, Maeda Y, Kinoshita T (2003). "Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge". J. Biol. Chem. 278 (16): 13959–67. doi:10.1074/jbc.M300586200. PMID12582175.
Vainauskas S, Menon AK (2004). "A conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol (GPI) recognition by GPI transamidase". J. Biol. Chem. 279 (8): 6540–5. doi:10.1074/jbc.M312191200. PMID14660601.
Vainauskas S, Menon AK (2005). "Endoplasmic reticulum localization of Gaa1 and PIG-T, subunits of the glycosylphosphatidylinositol transamidase complex". J. Biol. Chem. 280 (16): 16402–9. doi:10.1074/jbc.M414253200. PMID15713669.
Ho JC, Cheung ST, Patil M, et al. (2006). "Increased expression of glycosyl-phosphatidylinositol anchor attachment protein 1 (GPAA1) is associated with gene amplification in hepatocellular carcinoma". Int. J. Cancer. 119 (6): 1330–7. doi:10.1002/ijc.22005. PMID16642471.
