GLO1

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Glyoxalase I
File:GLO1 Leishmania major small fast2.ogg
Rendering based on 1bh5.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols GLO1 ; GLYI
External IDs Template:OMIM5 Template:MGI HomoloGene: 4880
EC number 4.4.1.5
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Glyoxalase I, also known as GLO1, is a human gene.[1] It is a Lactoylglutathione lyase.

The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: GLO1 glyoxalase I".

Further reading

  • Reinsmoen NL, Friend PS, Miller WV; et al. (1977). "Inheritance of recombinant HLA-GLO haplotype suggesting the gene sequence". Nature. 267 (5608): 276–8. PMID 141008.
  • Hansen HE, Eriksen B (1980). "HLA-GLO linkage analysis in 57 informative families". Hum. Hered. 29 (6): 355–60. PMID 511191.
  • Meo T, Douglas T, Rijnbeek AM (1977). "Glyoxalase I polymorphism in the mouse: a new genetic marker linked to H-2". Science. 198 (4314): 311–3. PMID 910130.
  • Kömpf J, Bissbort S, Gussmann S, Ritter H (1975). "Polymorphism of red cell glyoxalase I (EI: 4.4.1.5); a new genetic marker in man. Investigation of 169 mother-child combinations". Humangenetik. 27 (2): 141–3. PMID 1150236.
  • Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. PMID 1602151.
  • Goldman D, O'Brien SJ, Lucas-Derse S, Dean M (1992). "Linkage mapping of human polymorphic proteins identified by two-dimensional electrophoresis". Genomics. 11 (4): 875–84. PMID 1686020.
  • Kim NS, Umezawa Y, Ohmura S, Kato S (1993). "Human glyoxalase I. cDNA cloning, expression, and sequence similarity to glyoxalase I from Pseudomonas putida". J. Biol. Chem. 268 (15): 11217–21. PMID 7684374.
  • Ranganathan S, Walsh ES, Godwin AK, Tew KD (1993). "Cloning and characterization of human colon glyoxalase-I". J. Biol. Chem. 268 (8): 5661–7. PMID 8449929.
  • Ridderström M, Mannervik B (1996). "Optimized heterologous expression of the human zinc enzyme glyoxalase I.". Biochem. J. 314 ( Pt 2): 463–7. PMID 8670058.
  • Cameron AD, Olin B, Ridderström M; et al. (1997). "Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping". EMBO J. 16 (12): 3386–95. doi:10.1093/emboj/16.12.3386. PMID 9218781.
  • Armeni T, Pieri C, Marra M; et al. (1998). "Studies on the life prolonging effect of food restriction: glutathione levels and glyoxalase enzymes in rat liver". Mech. Ageing Dev. 101 (1–2): 101–10. PMID 9593316.
  • Ridderström M, Cameron AD, Jones TA, Mannervik B (1998). "Involvement of an active-site Zn2+ ligand in the catalytic mechanism of human glyoxalase I.". J. Biol. Chem. 273 (34): 21623–8. PMID 9705294.
  • Cameron AD, Ridderström M, Olin B; et al. (1999). "Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue". Biochemistry. 38 (41): 13480–90. PMID 10521255.
  • Ranganathan S, Ciaccio PJ, Walsh ES, Tew KD (2000). "Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation". Gene. 240 (1): 149–55. PMID 10564821.
  • Sakamoto H, Mashima T, Kizaki A; et al. (2000). "Glyoxalase I is involved in resistance of human leukemia cells to antitumor agent-induced apoptosis". Blood. 95 (10): 3214–8. PMID 10807791.
  • Sakamoto H, Mashima T, Sato S; et al. (2001). "Selective activation of apoptosis program by S-p-bromobenzylglutathione cyclopentyl diester in glyoxalase I-overexpressing human lung cancer cells". Clin. Cancer Res. 7 (8): 2513–8. PMID 11489834.
  • Lupidi G, Venardi G, Bollettini M; et al. (2002). "Purification and partial characterization of glyoxalase I from bovine brain". Prep. Biochem. Biotechnol. 31 (3): 305–16. PMID 11513094.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Vander Jagt DL, Hunsaker LA (2003). "Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyoxalase-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase". Chem. Biol. Interact. 143-144: 341–51. PMID 12604221.
  • Sergeev AS, Agapova RK, Bogadel'nikova IV, Perel'man MI (2003). "[The use of discrete characters in discriminant analysis for diagnosis of pulmonary tuberculosis and for classification of patients differing in treatment efficiency based on polymorphisms at nine codominant loci-HP, GC, TF, PI, PGM1, GLO1, C3, ACP1 and ESD]". Genetika. 39 (7): 996–1002. PMID 12942785.

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