GGH (gene)

Gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
PDB rendering based on 1l9x.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1l9x​
Identifiers
Symbols	GGH ; GH
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2881
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase), also known as GGH, is a human gene.

This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate.

Further reading

• Galivan J, Ryan T, Rhee M; et al. (1999). "Glutamyl hydrolase: properties and pharmacologic impact". Semin. Oncol. 26 (2 Suppl 6): 33–7. PMID 10598552.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• O'Connor BM, Rotundo RF, Nimec Z; et al. (1991). "Secretion of gamma-glutamyl hydrolase in vitro". Cancer Res. 51 (15): 3874–81. PMID 1713122.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chandler CJ, Wang TT, Halsted CH (1986). "Pteroylpolyglutamate hydrolase from human jejunal brush borders. Purification and characterization". J. Biol. Chem. 261 (2): 928–33. PMID 2867095.CS1 maint: Multiple names: authors list (link)
• Wang TT, Chandler CJ, Halsted CH (1986). "Intracellular pteroylpolyglutamate hydrolase from human jejunal mucosa. Isolation and characterization". J. Biol. Chem. 261 (29): 13551–5. PMID 3759978.CS1 maint: Multiple names: authors list (link)
• Yao R, Nimec Z, Ryan TJ, Galivan J (1996). "Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase". J. Biol. Chem. 271 (15): 8525–8. PMID 8621474.CS1 maint: Multiple names: authors list (link)
• Yao R, Schneider E, Ryan TJ, Galivan J (1996). "Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10134–8. PMID 8816764.CS1 maint: Multiple names: authors list (link)
• Rhee MS, Lindau-Shepard B, Chave KJ; et al. (1998). "Characterization of human cellular gamma-glutamyl hydrolase". Mol. Pharmacol. 53 (6): 1040–6. PMID 9614206.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yin D, Chave KJ, Macaluso CR; et al. (1999). "Structural organization of the human gamma-glutamyl hydrolase gene". Gene. 238 (2): 463–70. PMID 10570974.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li H, Ryan TJ, Chave KJ, Van Roey P (2002). "Three-dimensional structure of human gamma -glutamyl hydrolase. A class I glatamine amidotransferase adapted for a complex substate". J. Biol. Chem. 277 (27): 24522–9. doi:10.1074/jbc.M202020200. PMID 11953431.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Basrur V, Yang F, Kushimoto T; et al. (2003). "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins". J. Proteome Res. 2 (1): 69–79. PMID 12643545.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• He P, Varticovski L, Bowman ED; et al. (2004). "Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray". Hum. Pathol. 35 (10): 1196–209. PMID 15492986.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Eisele LE, Chave KJ, Lehning AC, Ryan TJ (2006). "Characterization of Human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer". Biochim. Biophys. Acta. 1764 (9): 1479–86. doi:10.1016/j.bbapap.2006.06.008. PMID 16945597.CS1 maint: Multiple names: authors list (link)
• Chi A, Valencia JC, Hu ZZ; et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hayashi H, Fujimaki C, Inoue K; et al. (2007). "Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population". Biol. Pharm. Bull. 30 (4): 839–41. PMID 17409534.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)