GC rich repressor elements
Jump to navigation
Jump to search
GC rich repressor element
Down regulation of smooth muscle myosin heavy chain (SM MHC) expression in cultured smooth muscle cells is associated with progressive methylation of a GC rich repressor element (GCGGGA) within the SM MHC promoter.[1]
References
1. Julian M Rozenberg, Daniel B Tesfu, Srilaxmi Musunuri, Joan M Taylor & Christopher P Mack (December 2014). DNA methylation of a GC repressor element in the smooth muscle myosin heavy chain promoter facilitates binding of the Notch-associated transcription factor RBPJ/CSL1. Arterioscler. Thromb. Vasc. Biol. 2014; 34(12):2624–2631. PMID: 25324571. doi:10.1161/ATVBAHA.114.304634. (Rozenberg et al. 2014)