GC (gene)

Group-specific component (vitamin D binding protein)
PDB rendering based on 1j78.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1j78​, 1j7e​, 1kw2​, 1kxp​, 1lot​, 1ma9​
Identifiers
Symbols	GC ; DBP; DBP/GC; VDBG; VDBP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 486
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Group-specific component (vitamin D binding protein), also known as GC, is a human gene.

The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues.

Further reading

• Svasti J, Kurosky A, Bennett A, Bowman BH (1979). "Molecular basis for the three major forms of human serum vitamin D binding protein (group-specific component)". Biochemistry. 18 (8): 1611–7. PMID 218624.CS1 maint: Multiple names: authors list (link)
• Mikkelsen M, Jacobsen P, Henningsen K (1977). "Possible localization of Gc-System on chromosome 4. Loss of long arm 4 material associated with father-child incompatibility within the Gc-System". Hum. Hered. 27 (2): 105–7. PMID 558959.CS1 maint: Multiple names: authors list (link)
• Braun A, Bichlmaier R, Cleve H (1992). "Molecular analysis of the gene for the human vitamin-D-binding protein (group-specific component): allelic differences of the common genetic GC types". Hum. Genet. 89 (4): 401–6. PMID 1352271.CS1 maint: Multiple names: authors list (link)
• Esteban C, Geuskens M, Ena JM; et al. (1992). "Receptor-mediated uptake and processing of vitamin D-binding protein in human B-lymphoid cells". J. Biol. Chem. 267 (14): 10177–83. PMID 1374401.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Szpirer C, Riviere M, Cortese R; et al. (1992). "Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2): 293–300. PMID 1535333.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. PMID 1602151.
• Yang F, Bergeron JM, Linehan LA; et al. (1990). "Mapping and conservation of the group-specific component gene in mouse". Genomics. 7 (4): 509–16. PMID 1696927.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang F, Luna VJ, McAnelly RD; et al. (1986). "Evolutionary and structural relationships among the group-specific component, albumin and alpha-fetoprotein". Nucleic Acids Res. 13 (22): 8007–17. PMID 2415926.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang F, Brune JL, Naylor SL; et al. (1986). "Human group-specific component (Gc) is a member of the albumin family". Proc. Natl. Acad. Sci. U.S.A. 82 (23): 7994–8. PMID 2415977.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cooke NE, David EV (1986). "Serum vitamin D-binding protein is a third member of the albumin and alpha fetoprotein gene family". J. Clin. Invest. 76 (6): 2420–4. PMID 2416779.
• Schoentgen F, Metz-Boutigue MH, Jollès J; et al. (1986). "Complete amino acid sequence of human vitamin D-binding protein (group-specific component): evidence of a three-fold internal homology as in serum albumin and alpha-fetoprotein". Biochim. Biophys. Acta. 871 (2): 189–98. PMID 2423133.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McNearney TA, Odell C, Holers VM; et al. (1987). "Herpes simplex virus glycoproteins gC-1 and gC-2 bind to the third component of complement and provide protection against complement-mediated neutralization of viral infectivity". J. Exp. Med. 166 (5): 1525–35. PMID 2824652.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang F, Naberhaus KH, Adrian GS; et al. (1987). "The vitamin D-binding protein gene contains conserved nucleotide sequences that respond to heavy metal, adipocyte and mitotic signals". Gene. 54 (2–3): 285–90. PMID 2958390.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cooke NE, Willard HF, David EV, George DL (1986). "Direct regional assignment of the gene for vitamin D binding protein (Gc-globulin) to human chromosome 4q11-q13 and identification of an associated DNA polymorphism". Hum. Genet. 73 (3): 225–9. PMID 3015768.CS1 maint: Multiple names: authors list (link)
• Nestler JE, McLeod JF, Kowalski MA; et al. (1987). "Detection of vitamin D binding protein on the surface of cytotrophoblasts isolated from human placentae". Endocrinology. 120 (5): 1996–2002. PMID 3552627.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pierce EA, Dame MC, Bouillon R; et al. (1986). "Monoclonal antibodies to human vitamin D-binding protein". Proc. Natl. Acad. Sci. U.S.A. 82 (24): 8429–33. PMID 3936035.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wooten MW, Nel AE, Goldschmidt-Clermont PJ; et al. (1985). "Identification of a major endogenous substrate for phospholipid/Ca2+-dependent kinase in pancreatic acini as Gc (vitamin D-binding protein)". FEBS Lett. 191 (1): 97–101. PMID 4054306.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Constans J, Oksman F, Viau M (1981). "Binding of the apo and holo forms of the serum vitamin D-binding protein to human lymphocyte cytoplasm and membrane by indirect immunofluorescence". Immunol. Lett. 3 (3): 159–62. PMID 7026425.CS1 maint: Multiple names: authors list (link)
• Braun A, Kofler A, Morawietz S, Cleve H (1994). "Sequence and organization of the human vitamin D-binding protein gene". Biochim. Biophys. Acta. 1216 (3): 385–94. PMID 7505619.CS1 maint: Multiple names: authors list (link)
• Swamy N, Roy A, Chang R; et al. (1995). "Affinity purification of human plasma vitamin D-binding protein". Protein Expr. Purif. 6 (2): 185–8. doi:10.1006/prep.1995.1023. PMID 7606167.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)