G12/G13

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guanine nucleotide binding protein (G protein) alpha 12
Identifiers
SymbolGNA12
Entrez2768
HUGO4380
OMIM604394
RefSeqNM_007353
UniProtQ03113
Other data
LocusChr. 7 p22.3
guanine nucleotide binding protein (G protein), alpha 13
Identifiers
SymbolGNA13
Entrez10672
HUGO4381
OMIM604406
RefSeqNM_006572
UniProtQ14344
Other data
LocusChr. 17 q24

G12/G13 subunits are alpha units of heterotrimeric G proteins which regulate cell process through the use of guanine nucleotide exchange factors.

They are not sensitive to pertussis toxin.[1]

Genes

References

  1. Harhammer R, Nürnberg B, Harteneck C, Leopoldt D, Exner T, Schultz G (1996). "Distinct biochemical properties of the native members of the G12 G-protein subfamily. Characterization of G alpha 12 purified from rat brain". Biochem. J. 319 ( Pt 1): 165–71. PMID 8870664.

External links

  • MP Strathmann, and MI Simon (1991). "G{alpha}12 and G{alpha}13 Subunits Define a Fourth Class of G Protein {alpha} Subunits". Proc. Natl. Acad Sci.. 88: 5582–6. doi:10.1073/pnas.88.13.5582.
  • Dhanasekaran N., Dermott J.M. (1996). "Signaling by the G12 class of G proteins". Cell. Sibnal.. 8: 235–45. PMID: 8842523 [1].
  • Wang D, Tan YC, Kreitzer GE, Nakai Y, Shan D, Zheng Y, Huang XY. (2006). "G proteins G12 and G13 control the dynamic turnover of growth factor-induced dorsal ruffles". J Biol Chem.. 281: 32660–7. PMID: 16943201 [2].
  • Shan D, Chen L, Wang D, Tan YC, Gu JL, Huang XY (2006). "The G protein G alpha(13) is required for growth factor-induced cell migration". Dev. Cell.. 10: 707–18. PMID: 16740474 [3].




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