Jump to: navigation, search
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
CAS Number
PubChem CID
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Molar mass458.54 g/mol
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

WikiDoc Resources for Fumagillin


Most recent articles on Fumagillin

Most cited articles on Fumagillin

Review articles on Fumagillin

Articles on Fumagillin in N Eng J Med, Lancet, BMJ


Powerpoint slides on Fumagillin

Images of Fumagillin

Photos of Fumagillin

Podcasts & MP3s on Fumagillin

Videos on Fumagillin

Evidence Based Medicine

Cochrane Collaboration on Fumagillin

Bandolier on Fumagillin

TRIP on Fumagillin

Clinical Trials

Ongoing Trials on Fumagillin at Clinical Trials.gov

Trial results on Fumagillin

Clinical Trials on Fumagillin at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Fumagillin

NICE Guidance on Fumagillin


FDA on Fumagillin

CDC on Fumagillin


Books on Fumagillin


Fumagillin in the news

Be alerted to news on Fumagillin

News trends on Fumagillin


Blogs on Fumagillin


Definitions of Fumagillin

Patient Resources / Community

Patient resources on Fumagillin

Discussion groups on Fumagillin

Patient Handouts on Fumagillin

Directions to Hospitals Treating Fumagillin

Risk calculators and risk factors for Fumagillin

Healthcare Provider Resources

Symptoms of Fumagillin

Causes & Risk Factors for Fumagillin

Diagnostic studies for Fumagillin

Treatment of Fumagillin

Continuing Medical Education (CME)

CME Programs on Fumagillin


Fumagillin en Espanol

Fumagillin en Francais


Fumagillin in the Marketplace

Patents on Fumagillin

Experimental / Informatics

List of terms related to Fumagillin

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Fumagillin is a complex biomolecule and used as an antimicrobial agent. It was isolated in 1949 from the microbial organism Aspergillus fumigatus.[1]


In animals

It was originally used against microsporidial parasites Nosema apis infections in honey bees.

Some studies found it to be effective against some myxozoan parasites, including Myxobolus cerebralis, an important parasite of fish; however, in the more rigorous tests required for U.S. Food and Drug Administration approval, it was ineffective.

There are reports that fumagillin controls Nosema ceranae,[2] which has recently been hypothesized as a possible cause of colony collapse disorder.[3][4] The latest report, however, has shown it to be ineffective against N. ceranae.[5] Fumagillin is also investigated as an inhibitor of malaria parasite growth.[6][7]

In humans

Fumagillin has been used in the treatment of microsporidiosis.[8][9] It is also an amebicide.[10]

Fumagillin can block blood vessel formation by binding to an enzyme methionine aminopeptidase 2[11] and for this reason, the compound, together with semisynthetic derivatives, are investigated as an angiogenesis inhibitor [12] in the treatment of cancer.

Preliminary clinical trials are being conducted by Zafgen into using the fumagillin analog beloranib for weight loss.[13]

According to Zbidah and coworkers from Germany fumagillin is toxic to erythrocytes in vitro.[14]

Total synthesis

Fumagillin and the related fumagillol (the hydrolysis product) have been a target in total synthesis, with several reported successful strategies, racemic, asymmetric and formal.[15][16][17][18][19][20][21][22][23]


  1. F. R. Hanson, T. E. Elbe, J. Bacteriol. 1949, 58, 527
  2. Williams, G.R., Sampson, M.A., Shutler, D., Rogers, R.E.L. (2008). "Does fumagillin control the recently detected invasive parasite Nosema ceranae in western honey bees (Apis mellifera)?". Journal of Invertebrate Pathology. 99 (3): 342–344. doi:10.1016/j.jip.2008.04.005. PMID 18550078.
  3. Sabin Russell (2007-04-26). "UCSF scientist tracks down suspect in honeybee deaths". San Francisco Chronicle.
  4. "Scientists Identify Pathogens That May Be Causing Global Honeybee Deaths" (Portable Document Format). Edgewood Chemical Biological Center. 2007-04-25.Template:Check
  5. Huang, Wei-Fone; Leellen Solter; Peter Yau; Brian Imai (7 March 2013). Schneider, David S, ed. "Nosema ceranae Escapes Fumagillin Control in Honey Bees". PLoS Pathogens. 9 (3): e1003185. doi:10.1371/journal.ppat.1003185.
  6. Xiaochun Chen et al. "Fumagillin and Fumarranol Interact with P. falciparum Methionine Aminopeptidase 2 and Inhibit Malaria Parasite Growth In Vitro and In Vivo". Chemistry & Biology, Vol. 16 Nr. 2 (2009) blz. 193-202. Template:Cite DOI
  7. Christopher Arico-Muendel et al. "Antiparasitic activities of novel, orally available fumagillin analogs". Bioorganic & Medicinal Chemistry Letters Vol. 19 Nr. 17 (2009), blz. 5128-5131 Template:Cite DOI
  8. Lanternier F, Boutboul D, Menotti J; et al. (February 2009). "Microsporidiosis in solid organ transplant recipients: two Enterocytozoon bieneusi cases and review". Transpl Infect Dis. 11 (1): 83–8. doi:10.1111/j.1399-3062.2008.00347.x. PMID 18803616.
  9. Molina JM, Tourneur M, Sarfati C; et al. (June 2002). "Fumagillin treatment of intestinal microsporidiosis". N. Engl. J. Med. 346 (25): 1963–9. doi:10.1056/NEJMoa012924. PMID 12075057.
  10. Lefkove B, Govindarajan B, Arbiser JL (August 2007). "Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors". Expert Rev Anti Infect Ther. 5 (4): 573–9. doi:10.1586/14787210.5.4.573. PMID 17678422.
  11. Gilbert, M. A. & Granath, W.O. Jr. (2003). "Whirling disease and salmonid fish: life cycle, biology, and disease". Journal of Parasitology. 89 (4): pp. 658–667. doi:10.1645/GE-82R. PMID 14533670.
  12. Template:Cite DOI
  13. "Zafgen Announces Positive Topline Phase 1b Data for ZGN-433 in Obesity". MedNews. Drugs.com. 5 January 2011.
  14. Zbidah, M; Lupescu, A; Jilani, K; Lang, F (2013). "Stimulation of suicidal erythrocyte death by fumagillin". Basic & clinical pharmacology & toxicology. 112 (5): 346–51. doi:10.1111/bcpt.12033. PMID 23121865.
  15. Template:Cite DOI
  16. Template:Cite DOI
  17. A Concise Synthesis of Fumagillol David A. Vosburg, Sven Weiler, Erik J. Sorensen Angewandte Chemie International Edition Volume 38, Issue 7, Date: April 1, 1999, Pages: 971-974 DOI
  18. Template:Cite DOI
  19. Template:Cite DOI
  20. Template:Cite DOI
  21. Template:Cite DOI
  22. Template:Cite DOI
  23. Template:Cite DOI