Formestane

Formestane

Gene therapy
Clinical data
Other names	4-hydroxyandrost-4-ene-3,17-dione
AHFS/Drugs.com	International Drug Names
ATC code	L02BG02 (WHO)
Physiological data
Legal status
Pharmacokinetic data
Identifiers
IUPAC name (8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
CAS Number	566-48-3 Y
PubChem Template:Abbreviation	11273
ChemSpider	10799 Y
UNII	PUB9T8T355
KEGG	D07260 Y
ChEBI	CHEBI:75172 N
ChEMBL	ChEMBL132530 Y
Chemical and physical data
Formula	C19H26O3
Molar mass	302.408 g/mol
3D model (JSmol)	Interactive image
SMILES O=C4C(/O)=C3/CC[C@@H]2[C@H](CC[C@@]1(C(=O)CC[C@H]12)C)[C@@]3(C)CC4
InChI InChI=1S/C19H26O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,22H,3-10H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1 Y Key:OSVMTWJCGUFAOD-KZQROQTASA-N Y
Template:XmarkY (what is this?)  (verify)

WikiDoc Resources for Formestane
Articles
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Evidence Based Medicine
Cochrane Collaboration on Formestane Bandolier on Formestane TRIP on Formestane
Clinical Trials
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Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Formestane NICE Guidance on Formestane NHS PRODIGY Guidance FDA on Formestane CDC on Formestane
Books
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Commentary
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Definitions
Definitions of Formestane
Patient Resources / Community
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Healthcare Provider Resources
Symptoms of Formestane Causes & Risk Factors for Formestane Diagnostic studies for Formestane Treatment of Formestane
Continuing Medical Education (CME)
CME Programs on Formestane
International
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Business
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Experimental / Informatics
List of terms related to Formestane

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Formestane (Lentaron) is a type I, steroidal aromatase inhibitor. It is used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women. It is available as an intramuscular depot injection.

Formestane is often used to suppress estrogen production from anabolic steroids or prohormones. It also acts as a prohormone to 4-hydroxytestosterone, an active steroid which displays weak androgenic activity in addition to acting as a mild aromatase inhibitor.

Formestane has poor oral bioavailability and as such is no longer popular as many orally active aromatase inhibitors have been identified.

It is selective.