Flumetasone

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Flumetasone
Flumetasone.png
Clinical data
Synonyms(6S,8S,9S,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration
Topical
ATC code
Pharmacokinetic data
MetabolismHepatic, CYP3A4-mediated
Identifiers
CAS Number
PubChem CID
UNII
KEGG
ChEMBL
E number{{#property:P628}}
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Chemical and physical data
FormulaC22H28F2O5
Molar mass410.452 g/mol
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Flumethasone (usually as the pivalic acid ester flumethasone pivalate, trade name Locacorten or Locorten) is a corticosteroid for topical use. It is available in combination with clioquinol, under the trade name Locacorten-Vioform (in some countries Locorten-Vioform), for the treatment of otitis externa and otomycosis.

Flumethasone shows fully 420 times the potency of cortisone in an animal model for anti-inflammatory activity.

Synthesis

Flumethasone synthesis.png

See also

References


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