Fludiazepam

Jump to navigation Jump to search
Fludiazepam
Clinical data
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • ?
Routes of
administration
Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability?
MetabolismHepatic
Elimination half-life?
ExcretionRenal
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC16H12ClFN2O
Molar mass302.7
3D model (JSmol)
  (verify)

WikiDoc Resources for Fludiazepam

Articles

Most recent articles on Fludiazepam

Most cited articles on Fludiazepam

Review articles on Fludiazepam

Articles on Fludiazepam in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Fludiazepam

Images of Fludiazepam

Photos of Fludiazepam

Podcasts & MP3s on Fludiazepam

Videos on Fludiazepam

Evidence Based Medicine

Cochrane Collaboration on Fludiazepam

Bandolier on Fludiazepam

TRIP on Fludiazepam

Clinical Trials

Ongoing Trials on Fludiazepam at Clinical Trials.gov

Trial results on Fludiazepam

Clinical Trials on Fludiazepam at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Fludiazepam

NICE Guidance on Fludiazepam

NHS PRODIGY Guidance

FDA on Fludiazepam

CDC on Fludiazepam

Books

Books on Fludiazepam

News

Fludiazepam in the news

Be alerted to news on Fludiazepam

News trends on Fludiazepam

Commentary

Blogs on Fludiazepam

Definitions

Definitions of Fludiazepam

Patient Resources / Community

Patient resources on Fludiazepam

Discussion groups on Fludiazepam

Patient Handouts on Fludiazepam

Directions to Hospitals Treating Fludiazepam

Risk calculators and risk factors for Fludiazepam

Healthcare Provider Resources

Symptoms of Fludiazepam

Causes & Risk Factors for Fludiazepam

Diagnostic studies for Fludiazepam

Treatment of Fludiazepam

Continuing Medical Education (CME)

CME Programs on Fludiazepam

International

Fludiazepam en Espanol

Fludiazepam en Francais

Business

Fludiazepam in the Marketplace

Patents on Fludiazepam

Experimental / Informatics

List of terms related to Fludiazepam

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Fludiazepam, marketed under the brand name Erispan[1][2] is a potent benzodiazepine and 2'-fluoro derivative of diazepam,[3] originally developed by Hoffman-La Roche in the 1960s.[4] It is marketed in Japan and Taiwan in the form of 0.25 mg tablets, making it around 40x more potent than diazepam. It exerts its pharmacological properties via enhancement of GABAergic inhibition.[5] Fludiazepam has 4 times more binding affinity for benzodiazepine receptors than diazepam.[6] It possesses anxiolytic,[7][8][9] anticonvulsant, sedative, hypnotic and skeletal muscle relaxant properties.[10]

As with all benzodiazepines, fludiazepam is used recreationally.[11]

References

  1. Su, TP.; Chen, TJ.; Hwang, SJ.; Chou, LF.; Fan, AP.; Chen, YC. (Aug 2002). "Utilization of psychotropic drugs in Taiwan: an overview of outpatient sector in 2000". Zhonghua Yi Xue Za Zhi (Taipei). 65 (8): 378–91. PMID 12455808.
  2. "Benzodiazepine Names". non-benzodiazepines.org.uk. Retrieved 2008-12-29.
  3. Neville, GA.; Beckstead, HD.; Shurvell, HF. (Feb 1994). "A Fourier transform-Raman and infrared vibrational study of delorazepam, fludiazepam, flurazepam, and tetrazepam". J Pharm Sci. 83 (2): 143–51. doi:10.1002/jps.2600830207. PMID 7909552.
  4. US Patent 3299053 -ARYL-JH-L,X-BENZODIAZEPIN-Z(LH)-ONES
  5. Tsuchiya, T.; Fukushima, H. (Apr 1978). "Effects of benzodiazepines and pentobarbitone on the gaba-ergic recurrent inhibition of hippocampal neurons". Eur J Pharmacol. 48 (4): 421–4. doi:10.1016/0014-2999(78)90169-3. PMID 648585.
  6. Nakatsuka, I.; Shimizu, H.; Asami, Y.; Katoh, T.; Hirose, A.; Yoshitake, A. (Jan 1985). "Benzodiazepines and their metabolites: relationship between binding affinity to the benzodiazepine receptor and pharmacological activity". Life Sci. 36 (2): 113–9. doi:10.1016/0024-3205(85)90089-X. PMID 2857046.
  7. Okada, S.; Ichiki, K.; Tanokuchi, S.; Ishii, K.; Hamada, H.; Ota, Z. (1994). "Effect of an anxiolytic on lipid profile in non-insulin-dependent diabetes mellitus". J Int Med Res. 22 (6): 338–42. PMID 7895897.
  8. Okada, S.; Ichiki, K.; Tanokuchi, S.; Ishii, K.; Hamada, H.; Ota, Z. (1995). "Improvement of stress reduces glycosylated haemoglobin levels in patients with type 2 diabetes". J Int Med Res. 23 (2): 119–22. PMID 7601294.
  9. Okada, S.; Ichiki, K.; Tanokuchi, S.; Ishii, K.; Hamada, H.; Ota, Z. (1995). "How blood pressure in patients with non-insulin-dependent diabetes mellitus is influenced by stress". J Int Med Res. 23 (5): 377–80. PMID 8529781.
  10. Inoue, H.; Maeno, Y.; Iwasa, M.; Matoba, R.; Nagao, M. (Sep 2000). "Screening and determination of benzodiazepines in whole blood using solid-phase extraction and gas chromatography/mass spectrometry". Forensic Sci Int. 113 (1–3): 367–73. doi:10.1016/S0379-0738(00)00226-7. PMID 10978650.
  11. Shimamine, M.; Masunari, T.; Nakahara, Y. (1993). "[Studies on identification of drugs of abuse by diode array detection. I. Screening-test and identification of benzodiazepines by HPLC-DAD with ICOS software system]". Eisei Shikenjo Hokoku (111): 47–56. PMID 7920567.

Template:Benzodiazepines Template:Anxiolytics