FN3K

Fructosamine 3 kinase
Identifiers
Symbols	FN3K ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 23336
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Fructosamine 3 kinase, also known as FN3K, is a human gene.

FN3K catalyzes phosphorylation of fructosamines formed by glycation, the nonenzymatic reaction of glucose with primary amines followed by Amadori rearrangement. Phosphorylation of fructosamines may initiate metabolism of the modified amine and result in deglycation of glycated proteins (Delpierre et al., 2000).[supplied by OMIM]

Further reading

• Delpierre G, Rider MH, Collard F; et al. (2000). "Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase". Diabetes. 49 (10): 1627–34. PMID 11016445.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Szwergold BS, Howell S, Beisswenger PJ (2001). "Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo". Diabetes. 50 (9): 2139–47. PMID 11522682.CS1 maint: Multiple names: authors list (link)
• Delpierre G, Collard F, Fortpied J, Van Schaftingen E (2002). "Fructosamine 3-kinase is involved in an intracellular deglycation pathway in human erythrocytes". Biochem. J. 365 (Pt 3): 801–8. doi:10.1042/BJ20020325. PMID 11975663.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Delpierre G, Van Schaftingen E (2004). "Fructosamine 3-kinase, an enzyme involved in protein deglycation". Biochem. Soc. Trans. 31 (Pt 6): 1354–7. doi:10.1042/ . PMID 14641062.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Delpierrre G, Vertommen D, Communi D; et al. (2004). "Identification of fructosamine residues deglycated by fructosamine-3-kinase in human hemoglobin". J. Biol. Chem. 279 (26): 27613–20. doi:10.1074/jbc.M402091200. PMID 15102834.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Delplanque J, Delpierre G, Opperdoes FR, Van Schaftingen E (2004). "Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein". J. Biol. Chem. 279 (45): 46606–13. doi:10.1074/jbc.M407678200. PMID 15331600.CS1 maint: Multiple names: authors list (link)
• Conner JR, Beisswenger PJ, Szwergold BS (2004). "The expression of the genes for fructosamine-3-kinase and fructosamine-3-kinase-related protein appears to be constitutive and unaffected by environmental signals". Biochem. Biophys. Res. Commun. 323 (3): 932–6. doi:10.1016/j.bbrc.2004.08.181. PMID 15381090.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Conner JR, Beisswenger PJ, Szwergold BS (2005). "Some clues as to the regulation, expression, function, and distribution of fructosamine-3-kinase and fructosamine-3-kinase-related protein". Ann. N. Y. Acad. Sci. 1043: 824–36. doi:10.1196/annals.1333.095. PMID 16037310.CS1 maint: Multiple names: authors list (link)
• Delpierre G, Veiga-da-Cunha M, Vertommen D; et al. (2006). "Variability in erythrocyte fructosamine 3-kinase activity in humans correlates with polymorphisms in the FN3K gene and impacts on haemoglobin glycation at specific sites". Diabetes Metab. 32 (1): 31–9. PMID 16523184.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Szwergold BS (2007). "Fructosamine-6-phosphates are deglycated by phosphorylation to fructosamine-3,6-bisphosphates catalyzed by fructosamine-3-kinase (FN3K) and/or fructosamine-3-kinase-related-protein (FN3KRP)". Med. Hypotheses. 68 (1): 37–45. doi:10.1016/j.mehy.2006.06.030. PMID 16920277.