FDXR

Ferredoxin reductase
Identifiers
Symbols	FDXR ; ADXR
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3033
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ferredoxin reductase, also known as FDXR, is a human gene.

This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants of this gene have been described although the full-length nature of only two that encode different isoforms have been determined.

Further reading

• Sparkes RS, Klisak I, Miller WL (1991). "Regional mapping of genes encoding human steroidogenic enzymes: P450scc to 15q23-q24, adrenodoxin to 11q22; adrenodoxin reductase to 17q24-q25; and P450c17 to 10q24-q25". DNA Cell Biol. 10 (5): 359–65. PMID 1863359.CS1 maint: Multiple names: authors list (link)
• Coghlan VM, Vickery LE (1991). "Site-specific mutations in human ferredoxin that affect binding to ferredoxin reductase and cytochrome P450scc". J. Biol. Chem. 266 (28): 18606–12. PMID 1917982.
• Lin D, Shi YF, Miller WL (1990). "Cloning and sequence of the human adrenodoxin reductase gene". Proc. Natl. Acad. Sci. U.S.A. 87 (21): 8516–20. PMID 2236061.CS1 maint: Multiple names: authors list (link)
• Usanov SA, Chernogolov AA, Honkakoski P; et al. (1990). "[Cholesterol-hydroxylating cytochrome P-450 from bovine adrenal cortex mitochondria and human placenta: immunochemical properties and structural characteristics]". Biokhimiia. 55 (5): 865–77. PMID 2393675.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sasano H, Sasano N, Okamoto M, Nonaka Y (1989). "Immunohistochemical demonstration of adrenodoxin reductase in bovine and human adrenals". Pathol. Res. Pract. 184 (5): 473–9. PMID 2748461.CS1 maint: Multiple names: authors list (link)
• Usanov SA, Honkakoski P, Lang MA; et al. (1989). "Comparison of the immunochemical properties of human placental and bovine adrenal cholesterol side-chain cleavage enzyme complex". Biochim. Biophys. Acta. 998 (2): 189–95. PMID 2790061.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Solish SB, Picado-Leonard J, Morel Y; et al. (1988). "Human adrenodoxin reductase: two mRNAs encoded by a single gene on chromosome 17cen----q25 are expressed in steroidogenic tissues". Proc. Natl. Acad. Sci. U.S.A. 85 (19): 7104–8. PMID 2845396.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mittal S, Zhu YZ, Vickery LE (1988). "Molecular cloning and sequence analysis of human placental ferredoxin". Arch. Biochem. Biophys. 264 (2): 383–91. PMID 2969697.CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Müller JJ, Lapko A, Bourenkov G; et al. (2001). "Adrenodoxin reductase-adrenodoxin complex structure suggests electron transfer path in steroid biosynthesis". J. Biol. Chem. 276 (4): 2786–9. doi:10.1074/jbc.M008501200. PMID 11053423.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gonzalez MI, Robins DM (2001). "Oct-1 preferentially interacts with androgen receptor in a DNA-dependent manner that facilitates recruitment of SRC-1". J. Biol. Chem. 276 (9): 6420–8. doi:10.1074/jbc.M008689200. PMID 11096094.
• Tuckey RC, Headlam MJ (2002). "Placental cytochrome P450scc (CYP11A1): comparison of catalytic properties between conditions of limiting and saturating adrenodoxin reductase". J. Steroid Biochem. Mol. Biol. 81 (2): 153–8. PMID 12137805.
• Liu G, Chen X (2002). "The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis". Oncogene. 21 (47): 7195–204. doi:10.1038/sj.onc.1205862. PMID 12370809.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Araya Z, Hosseinpour F, Bodin K, Wikvall K (2003). "Metabolism of 25-hydroxyvitamin D3 by microsomal and mitochondrial vitamin D3 25-hydroxylases (CYP2D25 and CYP27A1): a novel reaction by CYP27A1". Biochim. Biophys. Acta. 1632 (1–3): 40–7. PMID 12782149.CS1 maint: Multiple names: authors list (link)
• Thiboutot D, Jabara S, McAllister JM; et al. (2003). "Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1)". J. Invest. Dermatol. 120 (6): 905–14. doi:10.1046/j.1523-1747.2003.12244.x. PMID 12787114.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)