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EcoCyc is a bioinformatics database for the bacterium Escherichia coli K-12. The EcoCyc project performs literature-based curation of the E. coli genome, and of E. coli transcriptional regulation, transporters, and metabolic pathways.

EcoCyc is a regularly updated electronic encyclopedia that contains written summaries of E. coli genes, distilled from more than 16,000 scientific articles.

EcoCyc is also a computable description of the genome and cellular networks of E. coli that supports data mining and computational analyses.

Objects in the EcoCyc database describe each E. coli gene and gene product. Database objects also describe molecular interactions, including metabolic pathways, transport events, and the regulation of gene expression.

EcoCyc can be accessed through the EcoCyc web site, as a set of downloadable files, and in conjunction with the Pathway Tools software that can be installed locally on PC/Windows, Sun, and PC/Linux computers. The latter provides capabilities that go beyond the web version of EcoCyc.

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