Drotaverine

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Drotaverine
File:Drotaverine.svg
Clinical data
Routes of
administration
Oral, intravenous
ATC code
Pharmacokinetic data
BioavailabilityHighly variable
Protein binding80 to 95%
MetabolismHepatic
Elimination half-life7 to 12 hours
ExcretionFecal and renal
Identifiers
CAS Number
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
FormulaC24H31NO4
Molar mass397.507 g/mol

Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, structurally related to papaverine. Drotaverine is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects.

A small 2003 study found drotaverine to be nearly 80% effective in treating renal colic.[1] It has also been used to accelerate labor.[2]

References

  1. Romics I, Molnár DL, Timberg G; et al. (2003). "The effect of drotaverine hydrochloride in acute colicky pain caused by renal and ureteric stones". BJU Int. 92 (1): 92–6. doi:10.1046/j.1464-410X.2003.04262.x. PMID 12823389.
  2. Singh KC, Jain P, Goel N, Saxena A (2004). "Drotaverine hydrochloride for augmentation of labor". Int J Gynaecol Obstet. 84 (1): 17–22. PMID 14698825.


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