Differentiating autoimmune retinopathy from other diseases

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: M. Hassan, M.B.B.S

Overview

Autoimmune retinopathy should be differentiated from retinal vascular diseases such as Behçet and systemic lupus erythematosus, white-dot syndrome spectrum disorders (particularly acute zonal occult outer retinopathy (AZOOR)), retinal degenerative disorders (such as retinitis pigmentosa (RP) and cone-rod dystrophy), and non-infectious and infectious uveitis syndromes.

Differentiating Autoimmune Retinopathy from other Diseases

In early stages of autoimmune retinopathy (AIR), the visual acuity is preserved, but it progressively gets worse.  Patients report of transient dimming of the vision, which may be mistaken for other retinal vascular diseases such as Behçet and systemic lupus erythematosus[1]

Other differential diagnosis of AIR include: white-dot syndrome spectrum disorders (particularly acute zonal occult outer retinopathy (AZOOR)), retinal degenerative disorders (such as retinitis pigmentosa (RP) and cone-rod dystrophy), and non-infectious and infectious uveitis syndromes.

Due to the presence of anti-retinal antibodies, and overlapping findings and symptoms, it is difficult to differentiate between retinitis pigmentosa and autoimmune retinopathy. [2]

References

  1. Canamary AM, Takahashi WY, Sallum JMF (2018). "Autoimmune retinopathy: A Review". Int J Retina Vitreous. 4: 1. doi:10.1186/s40942-017-0104-9. PMC 5759752. PMID 29340169.
  2. Grange L, Dalal M, Nussenblatt RB, Sen HN (2014). "Autoimmune retinopathy". Am J Ophthalmol. 157 (2): 266–272.e1. doi:10.1016/j.ajo.2013.09.019. PMC 3946999. PMID 24315290.


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