Desoxymethyltestosterone

Jump to: navigation, search
Desoxymethyltestosterone
Clinical data
SynonymsDesoxymethyltestosterone, Madol, 17α-methyl-5α-androst-2-en-17β-ol
Pregnancy
category
  • X
Routes of
administration
Oral, IM, Transdermal
Identifiers
CAS Number
PubChem CID
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC20H32O
Molar mass288.46748 g/mol

WikiDoc Resources for Desoxymethyltestosterone

Articles

Most recent articles on Desoxymethyltestosterone

Most cited articles on Desoxymethyltestosterone

Review articles on Desoxymethyltestosterone

Articles on Desoxymethyltestosterone in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Desoxymethyltestosterone

Images of Desoxymethyltestosterone

Photos of Desoxymethyltestosterone

Podcasts & MP3s on Desoxymethyltestosterone

Videos on Desoxymethyltestosterone

Evidence Based Medicine

Cochrane Collaboration on Desoxymethyltestosterone

Bandolier on Desoxymethyltestosterone

TRIP on Desoxymethyltestosterone

Clinical Trials

Ongoing Trials on Desoxymethyltestosterone at Clinical Trials.gov

Trial results on Desoxymethyltestosterone

Clinical Trials on Desoxymethyltestosterone at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Desoxymethyltestosterone

NICE Guidance on Desoxymethyltestosterone

NHS PRODIGY Guidance

FDA on Desoxymethyltestosterone

CDC on Desoxymethyltestosterone

Books

Books on Desoxymethyltestosterone

News

Desoxymethyltestosterone in the news

Be alerted to news on Desoxymethyltestosterone

News trends on Desoxymethyltestosterone

Commentary

Blogs on Desoxymethyltestosterone

Definitions

Definitions of Desoxymethyltestosterone

Patient Resources / Community

Patient resources on Desoxymethyltestosterone

Discussion groups on Desoxymethyltestosterone

Patient Handouts on Desoxymethyltestosterone

Directions to Hospitals Treating Desoxymethyltestosterone

Risk calculators and risk factors for Desoxymethyltestosterone

Healthcare Provider Resources

Symptoms of Desoxymethyltestosterone

Causes & Risk Factors for Desoxymethyltestosterone

Diagnostic studies for Desoxymethyltestosterone

Treatment of Desoxymethyltestosterone

Continuing Medical Education (CME)

CME Programs on Desoxymethyltestosterone

International

Desoxymethyltestosterone en Espanol

Desoxymethyltestosterone en Francais

Business

Desoxymethyltestosterone in the Marketplace

Patents on Desoxymethyltestosterone

Experimental / Informatics

List of terms related to Desoxymethyltestosterone


Overview

Desoxymethyltestosterone (Madol) is an anabolic steroid. It was one of the first "designer steroids" to be marketed as a performance-enhancing drug to athletes and bodybuilders. In animal studies it has been found to be a powerful androgen approximately half as potent as dihydrotestosterone, but caused serious side effects that are typical of 17α-alkylated steroids, such as liver damage and left ventricular hypertrophy.[1]

Desoxymethyltestosterone is sometimes referred to as "DMT", though it is not the same compound as the hallucinogen Dimethyltryptamine, also known as DMT.

Desoxymethyltestosterone was invented in 1961 by Max Huffman who obtained a patent on the compound. It was never brought to market as commercial drug and existed only in some obscure journal articles until it was rediscovered by chemist Patrick Arnold in 2005. Arnold produced desoxymethyltestosterone and supplied it to Victor Conte of Bay Area Laboratory Co-operative (BALCO), an American nutritional supplement company.[2]

Desoxymethyltestosterone is unusual in that it is structurally a 2-ene compound, lacking the 3-keto group present on nearly all commercial anabolic steroids. This does not mean it is a weak compound, and clinical research has determined that it is a fairly potent oral agent. Rat studies indicate desoxymethyltestosterone has an anabolic effect 160% that of testosterone while being only 60% as androgenic giving it a Q ratio of 6.5:1. Because of this favorable ratio, experiments in orchiectomised rats have demonstrated that treatment with desoxymethyltestosterone resulted only in a stimulation of the weight of the levator ani muscle; the prostate and seminal vesicle weights remained unaffected. In humans, this may mean that it would be less likely to cause unfavorable androgenic side effects like hair loss, acne and prostate enlargement.

Interestingly, although desoxymethyltestosterone is completely synthetic in origin, it is nearly identical in structure to delta2-androstenol, a naturally-occurring pheromone found in elephant urine.

References

  1. Diel P, Friedel A, Geyer H, Kamber M, Laudenbach-Leschowsky U, Schänzer W, Thevis M, Vollmer G, Zierau O. Characterisation of the pharmacological profile of desoxymethyltestosterone (Madol), a steroid misused for doping. Toxicology Letters. 2007 Feb 28;169(1):64-71.
  2. "Chemist Who Created "The Clear" Sentenced" (Press release). United States Attorney for the Northern District of California. 2006-08-04. Retrieved 2007-10-08.

de:Desoxymethyltestosteron



Linked-in.jpg