Defensin, alpha 1

Defensin, alpha 1
PDB rendering based on 1dfn.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1dfn​, 1zmh​, 1zmi​, 1zmk​, 2pm1​, 2pm4​, 2pm5​
Identifiers
Symbols	DEFA1 ; DEF1; DEFA2; HNP-1; HP-1; MGC138393; MRS; DEF3; HNP-3; HNP3; HP-3
External IDs	Template:OMIM5 HomoloGene: 37877
Gene ontology Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Defensin, alpha 1, also known as DEFA1, is a human gene.

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. It differs from defensin, alpha 3 by only one amino acid.

Further reading

• Lehrer RI, Lichtenstein AK, Ganz T (1993). "Defensins: antimicrobial and cytotoxic peptides of mammalian cells". Annu. Rev. Immunol. 11: 105–28. doi:10.1146/annurev.iy.11.040193.000541. PMID 8476558.CS1 maint: Multiple names: authors list (link)
• Corda D, Di Girolamo M (2003). "Mono-ADP-ribosylation: a tool for modulating immune response and cell signaling". Sci. STKE. 2002 (163): PE53. doi:10.1126/stke.2002.163.pe53. PMID 12488509.
• Valore EV, Ganz T (1992). "Posttranslational processing of defensins in immature human myeloid cells". Blood. 79 (6): 1538–44. PMID 1339298.
• Zhang XL, Selsted ME, Pardi A (1992). "NMR studies of defensin antimicrobial peptides. 1. Resonance assignment and secondary structure determination of rabbit NP-2 and human HNP-1". Biochemistry. 31 (46): 11348–56. PMID 1445872.CS1 maint: Multiple names: authors list (link)
• Pardi A, Zhang XL, Selsted ME; et al. (1992). "NMR studies of defensin antimicrobial peptides. 2. Three-dimensional structures of rabbit NP-2 and human HNP-1". Biochemistry. 31 (46): 11357–64. PMID 1445873.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hill CP, Yee J, Selsted ME, Eisenberg D (1991). "Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization". Science. 251 (5000): 1481–5. PMID 2006422.CS1 maint: Multiple names: authors list (link)
• Bateman A, Singh A, Shustik C; et al. (1991). "The isolation and identification of multiple forms of the neutrophil granule peptides from human leukemic cells". J. Biol. Chem. 266 (12): 7524–30. PMID 2019582.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wagner MJ, Ge Y, Siciliano M, Wells DE (1991). "A hybrid cell mapping panel for regional localization of probes to human chromosome 8". Genomics. 10 (1): 114–25. PMID 2045096.CS1 maint: Multiple names: authors list (link)
• Sparkes RS, Kronenberg M, Heinzmann C; et al. (1989). "Assignment of defensin gene(s) to human chromosome 8p23". Genomics. 5 (2): 240–4. PMID 2793180.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Selsted ME, Harwig SS (1989). "Determination of the disulfide array in the human defensin HNP-2. A covalently cyclized peptide". J. Biol. Chem. 264 (7): 4003–7. PMID 2917986.
• Wiedemann LM, Francis GE, Lamb RF; et al. (1989). "Differentiation stage-specific expression of a gene during granulopoiesis". Leukemia. 3 (3): 227–34. PMID 2918759.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ganz T, Selsted ME, Szklarek D; et al. (1985). "Defensins. Natural peptide antibiotics of human neutrophils". J. Clin. Invest. 76 (4): 1427–35. PMID 2997278.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Daher KA, Lehrer RI, Ganz T, Kronenberg M (1988). "Isolation and characterization of human defensin cDNA clones". Proc. Natl. Acad. Sci. U.S.A. 85 (19): 7327–31. PMID 3174637.CS1 maint: Multiple names: authors list (link)
• Mars WM, van Tuinen P, Drabkin HA; et al. (1988). "A myeloid-related sequence that localizes to human chromosome 8q21.1-22". Blood. 71 (6): 1713–9. PMID 3370315.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Selsted ME, Harwig SS, Ganz T; et al. (1985). "Primary structures of three human neutrophil defensins". J. Clin. Invest. 76 (4): 1436–9. PMID 4056036.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Panyutich AV, Hiemstra PS, van Wetering S, Ganz T (1995). "Human neutrophil defensin and serpins form complexes and inactivate each other". Am. J. Respir. Cell Mol. Biol. 12 (3): 351–7. PMID 7873202.CS1 maint: Multiple names: authors list (link)
• Date Y, Nakazato M, Shiomi K; et al. (1994). "Localization of human neutrophil peptide (HNP) and its messenger RNA in neutrophil series". Ann. Hematol. 69 (2): 73–7. PMID 8080882.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Linzmeier R, Michaelson D, Liu L, Ganz T (1993). "The structure of neutrophil defensin genes". FEBS Lett. 326 (1–3): 299–300. PMID 8325384.CS1 maint: Multiple names: authors list (link)
• Linzmeier R, Michaelson D, Liu L, Ganz T (1993). "The structure of neutrophil defensin genes". FEBS Lett. 321 (2–3): 267–73. PMID 8477861.CS1 maint: Multiple names: authors list (link)