DNA adduct

Jump to: navigation, search

WikiDoc Resources for DNA adduct

Articles

Most recent articles on DNA adduct

Most cited articles on DNA adduct

Review articles on DNA adduct

Articles on DNA adduct in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on DNA adduct

Images of DNA adduct

Photos of DNA adduct

Podcasts & MP3s on DNA adduct

Videos on DNA adduct

Evidence Based Medicine

Cochrane Collaboration on DNA adduct

Bandolier on DNA adduct

TRIP on DNA adduct

Clinical Trials

Ongoing Trials on DNA adduct at Clinical Trials.gov

Trial results on DNA adduct

Clinical Trials on DNA adduct at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on DNA adduct

NICE Guidance on DNA adduct

NHS PRODIGY Guidance

FDA on DNA adduct

CDC on DNA adduct

Books

Books on DNA adduct

News

DNA adduct in the news

Be alerted to news on DNA adduct

News trends on DNA adduct

Commentary

Blogs on DNA adduct

Definitions

Definitions of DNA adduct

Patient Resources / Community

Patient resources on DNA adduct

Discussion groups on DNA adduct

Patient Handouts on DNA adduct

Directions to Hospitals Treating DNA adduct

Risk calculators and risk factors for DNA adduct

Healthcare Provider Resources

Symptoms of DNA adduct

Causes & Risk Factors for DNA adduct

Diagnostic studies for DNA adduct

Treatment of DNA adduct

Continuing Medical Education (CME)

CME Programs on DNA adduct

International

DNA adduct en Espanol

DNA adduct en Francais

Business

DNA adduct in the Marketplace

Patents on DNA adduct

Experimental / Informatics

List of terms related to DNA adduct


Overview

A DNA adduct is an abnormal piece of DNA covalently-bonded to a cancer-causing chemical. This has shown to be the start of a cancerous cell, or carcinogenesis. DNA adducts in scientific experiments are used as bio-markers and as such are themselves measured to reflect quantitatively, for comparison, the amount of cancer in the subject, i.e. rats or other living animals. Under experimental conditions for study, such DNA adducts are induced by known carcinogens, of which commonly used is DMBA, chemically structured and named as 7,12-Dimethyl-benz[a] Anthracene . For example, a scientific journal that writes "DMBA - DNA adduct" is referring to a piece of DNA that has the chemical DMBA attached to it. The presence of such adduct indicates the presence of cancer in the subject animal.[1]

Other examples : - acetaldehyde DNA Adducts. Note: acetaldehyde is a major component of cigarette smoke.

DNA Damage

When a chemical bonds to DNA, the DNA becomes damaged, and proper and complete replication cannot occur to make the normal intended cell. This would be the start of a mutation, or mutagenesis, and without proper DNA repair (DNA repair happens naturally under normal circumstances), this can lead to carcinogenesis, the beginnings of cancer.[2]

References

  1. "Biosciences - DNA Adducts". Lawrence Livermore National Laboratory. Retrieved January 19, 2007.
  2. "DNA Adducts". www.eclipsescience.com. Retrieved January 19, 2007.



Linked-in.jpg