DNA-binding protein

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DNA-binding proteins are proteins that comprise any of many DNA-binding domains and thus have a specific or general affinity to DNA.

DNA-binding proteins include transcription factors which modulate the process of transcription, nucleases which cleave DNA molecules, and histones which are involved in DNA packaging in the cell nucleus.

Sequence-specific DNA-binding proteins generally interact with the major groove of B-DNA, because it exposes more functional groups that identify a base pair.

The specificity of DNA-binding proteins can be identified using the DNase footprinting technique.

DNA binding proteins consist of the zinc finger, the helix turn helix, and the leucine zipper (including others).

See also

External links

it:DNA-binding protein