Clonazepam drug interactions

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

List of drug interactions

Phenytoin, carbamazepine and phenobarbital

Ranitidine and propantheline

Fluoxetine

Cytochrome P-450 inducers

Pharmacodynamic interactions



Phenytoin, carbamazepine and phenobarbital

lonazepam does not appear to alter the pharmacokinetics of phenytoin, carbamazepine or phenobarbital. The effect of Clonazepam on the metabolism of other drugs has not been investigated. Return to top

Ranitidine and propantheline

Ranitidine and propantheline, agents that decrease stomach acidity, do not greatly alter Clonazepam pharmacokinetics. Return to top

Fluoxetine

Fluoxetine does not affect the pharmacokinetics of Clonazepam. Return to top

Cytochrome P-450 inducers

Cytochrome P-450 inducers, such as phenytoin, carbamazepine and phenobarbital induce Clonazepam metabolism, causing an approximately 30% decrease in plasma Clonazepam levels. Although clinical studies have not been performed, based on the involvement of the cytochrome P-450 3A family in Clonazepam metabolism, inhibitors of this enzyme system, notably oral antifungal agents, should be used cautiously in patients receiving Clonazepam. Return to top

Pharmacodynamic interactions

The CNS-depressant action of the benzodiazepine class of drugs may be potentiated by alcohol, narcotics, barbiturates, nonbarbiturate hypnotics, antianxiety agents, the phenothiazines, thioxanthene and butyrophenone classes of antipsychotic agents, monoamine oxidase inhibitors and the tricyclic antidepressants, and by other anticonvulsant drugs. Return to top

Complete list of drug interactions

Major Interactions

Moderate Interactions

Minor Interactions





Adapted from the FDA Package Insert.


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