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Clinical data
SynonymsCiramadol, WY-15705
CAS Number
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
Molar mass249.349 g/mol

Ciramadol (WY-15705) is an opioid analgesic that was developed in the late 1970s.[1]

Ciramadol is a mixed agonist-antagonist for mu opioid receptors with relatively low abuse potential[2] and a ceiling on respiratory depression[3] which makes it a relatively safe drug. It has a slightly higher potency and effectiveness as an analgesic than codeine,[4] but is weaker than morphine.[5] Other side effects include sedation and nausea but these are generally less severe than with other similar drugs.[6]


  1. Cochrane AD, Bell R, Sullivan JR, Shaw J. Ciramadol. A new analgesic. Medical Journal of Australia. 1979 Nov 3;2(9):501-2.
  2. Preston KL, Bigelow GE, Liebson IA. Comparative evaluation of morphine, pentazocine and ciramadol in postaddicts. Journal of Pharmacology and Experimental Therapeutics. 1987 Mar;240(3):900-10.
  3. Romagnoli A, Keats AS. Low ceiling respiratory depression by ciramadol. International Journal of Clinical Pharmacology Research. 1986;6(6):451-5.
  4. Downing JW, Brock-Utne JG, Holloway AM. Ciramadol - a new synthetic analgesic. A double-blind comparison with oral codeine for postoperative pain relief. South African Medical Journal. 1983 Dec 10;64(25):978-82.
  5. Powell WF. A double-blind comparison of multiple intramuscular doses of ciramadol, morphine, and placebo for the treatment of postoperative pain. Anesthesia and Analgesia. 1985 Nov;64(11):1101-7.
  6. Stambaugh JE Jr, McAdams J. Comparison of the analgesic efficacy and safety oral ciramadol, codeine, and placebo in patients with chronic cancer pain. Journal of Clinical Pharmacology. 1987 Feb;27(2):162-6.


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