Chymopapain

Chymopapain

Clinical data
Routes of administration	Injection into intervertebral disc
ATC code	M09AB01 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
ChemSpider	NA Y
UNII	1UK146T40N
ChEMBL	ChEMBL1201626 N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
NY (what is this?)  (verify)

WikiDoc Resources for Chymopapain
Articles
Most recent articles on Chymopapain Most cited articles on Chymopapain Review articles on Chymopapain Articles on Chymopapain in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Chymopapain Images of Chymopapain Photos of Chymopapain Podcasts & MP3s on Chymopapain Videos on Chymopapain
Evidence Based Medicine
Cochrane Collaboration on Chymopapain Bandolier on Chymopapain TRIP on Chymopapain
Clinical Trials
Ongoing Trials on Chymopapain at Clinical Trials.gov Trial results on Chymopapain Clinical Trials on Chymopapain at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Chymopapain NICE Guidance on Chymopapain NHS PRODIGY Guidance FDA on Chymopapain CDC on Chymopapain
Books
Books on Chymopapain
News
Chymopapain in the news Be alerted to news on Chymopapain News trends on Chymopapain
Commentary
Blogs on Chymopapain
Definitions
Definitions of Chymopapain
Patient Resources / Community
Patient resources on Chymopapain Discussion groups on Chymopapain Patient Handouts on Chymopapain Directions to Hospitals Treating Chymopapain Risk calculators and risk factors for Chymopapain
Healthcare Provider Resources
Symptoms of Chymopapain Causes & Risk Factors for Chymopapain Diagnostic studies for Chymopapain Treatment of Chymopapain
Continuing Medical Education (CME)
CME Programs on Chymopapain
International
Chymopapain en Espanol Chymopapain en Francais
Business
Chymopapain in the Marketplace Patents on Chymopapain
Experimental / Informatics
List of terms related to Chymopapain

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Chymopapain (EC 3.4.22.6, chymopapain A, chymopapain B, chymopapain S, brand name Chymodiactin) is a proteolytic enzyme isolated from the latex of papaya (Carica papaya). It is a medication used to treat herniated lower lumbar discs in the spine. Chymopapain injections are normally given under local, rather than general, anaesthesia. The dose for a single intervertebral disc is 2 to 4 nanokatals, with a maximum dose per patient of 8 nanokatals. The procedure is referred to as chemonucleolysis.

The sale and distribution of chymopapain was discontinued in the United States on January 27, 2003 after the company producing it decided to stop selling worldwide.

Side effects

Serious side effects from the use of chymopapain include anaphylaxis, paralysis of the legs, or death.

See also

• Papain

External links

• The MEROPS online database for peptidases and their inhibitors: C01.002
• Data sheet for Papain from BIOZYM