Chorioamnionitis history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Adnan Ezici, M.D[2]
Overview
The hallmark of chorioamnionitis is maternal fever. The presence of uterine tenderness, purulent/foul-smelling amniotic fluid, and maternal/fetal tachycardia is suggestive of chorioamnionitis.
History
History of a patient with chorioamnionitis may include the following:
- Blood type A and 0[1]
- Past medical history
- Immunocompromised state that might be due either to primary immunodeficieny disorders or secondary to another condition[2]
- Secondary diseases or conditions associated with immunocompromised state include:[2]
- Human Immunodeficiency Virus (HIV) infection
- Hematopoietic stem cell transplantation
- Medications (corticosteroids, chemotherapeutics, immunomodulators, immunosuppressive agents after solid organ transplantions or for the prevention of graft-versus-ghost disease after bone marrow transplantation)
- Hematologic malignancies
- Diabetes mellitus
- Asplenia
- Protein-losing enteropathy
- Nephrotic syndrome
- Systemic lupus erythematosus
- End-stage renal disease
- Cirrhosis
- Secondary diseases or conditions associated with immunocompromised state include:[2]
- Sexually transmitted diseases (STDs)
- Immunocompromised state that might be due either to primary immunodeficieny disorders or secondary to another condition[2]
- Social history[3][4]
Symptoms
The hallmark of chorioamnionitis is maternal fever. The presence of uterine tenderness, purulent/foul-smelling amniotic fluid, and maternal/fetal tachycardia is suggestive of chorioamnionitis.[3]
- The most important clinical finding among patients with chorioamnionitis is fever, and temperature > 100.4 F should be defined as abnormal during pregnancy.
- Although uterine tenderness is an important clinical finding, it might be challenging to differentiate uterine tenderness from the pain of the labor or conditions such as placental abruption. Also, the patient might not be able to feel the pain due to the effects of analgesics and anesthetic procedures.
- The presence of purulent/foul-smelling amniotic fluid depends on the responsible microorganism and the severity of the chorioamnionitis.
- Maternal tachycardia (>100 per minute) and fetal tachycardia (>160 per minute) are important and common clinical findings of chorioamnionitis.
References
- ↑ Aly H, Alhabashi G, Hammad TA, Owusu-Ansah S, Bathgate S, Mohamed M (July 2008). "ABO phenotype and other risk factors associated with chorioamnionitis". J Pediatr. 153 (1): 16–8. doi:10.1016/j.jpeds.2008.02.008. PMID 18571527.
- ↑ 2.0 2.1 Dropulic LK, Lederman HM (August 2016). "Overview of Infections in the Immunocompromised Host". Microbiol Spectr. 4 (4). doi:10.1128/microbiolspec.DMIH2-0026-2016. PMID 27726779.
- ↑ 3.0 3.1 Tita AT, Andrews WW (June 2010). "Diagnosis and management of clinical chorioamnionitis". Clin Perinatol. 37 (2): 339–54. doi:10.1016/j.clp.2010.02.003. PMC 3008318. PMID 20569811.
- ↑ Alexander JM, McIntire DM, Leveno KJ (August 1999). "Chorioamnionitis and the prognosis for term infants". Obstet Gynecol. 94 (2): 274–8. doi:10.1016/s0029-7844(99)00256-2. PMID 10432142.