Chloroxine

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Chloroxine
Chloroxine.png
Clinical data
Trade namesCapitrol
Synonymscloroxinum, kloroxin, chlorquinol, dichlorchinolinolum, halquinol(s)
AHFS/Drugs.comMicromedex Detailed Consumer Information
ATC code
  • none
Legal status
Legal status
Identifiers
PubChem CID
ChemSpider
UNII
ChEMBL
E number{{#property:P628}}
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Chemical and physical data
FormulaC9H5Cl2NO
Molar mass214 g/mol
3D model (JSmol)

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Chloroxine (trade name Capitrol; Kloroxin, Dichlorchinolinol, chlorquinol, halquinol(s));[citation needed] Latin cloroxinum, dichlorchinolinolum) is an antibacterial drug.[1] Oral formulations (under trade name such as Endiaron[2]) are used in infectious diarrhea, disorders of the intestinal microflora (e.g. after antibiotic treatment), giardiasis, inflammatory bowel disease. It is also useful for dandruff and seborrheic dermatitis.,[3] as used in shampoos (Capitrol) and dermal creams like (Valpeda, Triaderm).

Mechanism of action

Chloroxine has bacteriostatic, fungistatic and antiprotozoal properties. It is effective against Streptococci, Staphylococci, Candida, Candida albicans, Shigella and Trichomonads.

The pharma reference also says that it does not adversely affects the natural intestinal microflora, however this claim is unsourced.

Adverse effects

Rarely occurs, but may cause nausea and vomiting associated with oral administration. It may also cause skin irritation.

Pregnancy and lactation

The FDA lists chloroxine in Pregnancy Category C (risk cannot be ruled out) because no pregnancy studies on the medication have been performed with animals or humans. For this reason, use of chloroxine oral or topical during pregnancy or when breast-feeding is not recommended.[4]

History

First prepared in 1888 by A. Hebebrand.[5]

References


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