Central pontine myelinolysis epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]

Overview

The prevalence of central pontine myelinolysis is approximately 250–500 per 100,000 in the general population. Among hospitalized patients in the ICU the incidence of central pontine myelinolysis is approximately 2500 per 100,000 patients. Among patients undergoing liver transplantation the incidence of central pontine myelinolysis is approximately 10,000 per 100,000 patients. The case-mortality rate of central pontine myelinolysis is approximately 12%. Patients of all age groups may develop central pontine myelinolysis but the incidence of central pontine myelinolysis increases with age. There is no racial predilection to central pontine myelinolysis. Central pontine myelinolysis affects men and women equally. There is no regional predilection to central pontine myelinolysis.

Epidemiology and Demographics

Incidence and prevalence

  • The prevalence of central pontine myelinolysis is approximately 250–500 per 100,000 in the general population.[1]
  • Among hospitalized patients in the ICU the incidence of central pontine myelinolysis is approximately 2500 per 100,000 patients.[2][1]
  • Among patients undergoing liver transplantation the incidence of central pontine myelinolysis is approximately 10,000 per 100,000 patients.[2][3][1]

Mortality rate

Age

  • Patients of all age groups may develop central pontine myelinolysis but the incidence of central pontine myelinolysis increases with age.

Race

  • There is no racial predilection to central pontine myelinolysis.

Gender

  • Central pontine myelinolysis affects men and women equally.[4]

Region

  • There is no regional predilection to central pontine myelinolysis.

References

  1. 1.0 1.1 1.2 1.3 Rao PB, Azim A, Singh N, Baronia AK, Kumar A, Poddar B (2015). "Osmotic demyelination syndrome in Intensive Care Unit". Indian J Crit Care Med. 19 (3): 166–9. doi:10.4103/0972-5229.152760. PMC 4366916. PMID 25810613.
  2. 2.0 2.1 Menger H, Jörg J (1999). "Outcome of central pontine and extrapontine myelinolysis (n = 44)". J Neurol. 246 (8): 700–5. PMID 10460448.
  3. Lampl C, Yazdi K (2002). "Central pontine myelinolysis". Eur Neurol. 47 (1): 3–10. doi:10.1159/000047939. PMID 11803185.
  4. Bansal LR, Zinkus T (2019). "Osmotic Demyelination Syndrome in Children". Pediatr Neurol. 97: 12–17. doi:10.1016/j.pediatrneurol.2019.03.018. PMID 31128892.

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