Cefpirome adverse reactions

Cefpirome
CEFROM® Package Insert
Composition
Properties
Indications
Microbiology
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Dosage and Administration
How Supplied

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Adverse Reactions

Hypersensitivity reactions: Allergic skin reactions (rash, urticaria), itching, drug fever and severe acute allergic (anaphylactic) reactions may occur.

Effects on the gastrointestinal tract: Nausea and vomiting, abdominal pain, diarrhea in very rare cases of pseudomembranous colitis.

Effects on liver function: Raise in serum liver enzymes (AST, ALT, LDH, alkaline phosphatase), increase in serum bilirubin.

Effects on renal function: Increases in serum creatinine (in rare cases necessitating discontinuation of treatment) and urea. In rare instances, interstitial nephritis may occur with cephalosporins.

Changes in blood constituents: Thrombocytopenia; eosinophilia; very rarely hemotytic anaemia. As with other beta laclam antibiotics (particularly if given over long periods), granulocytopenia and, more rarefy, agranulocytosis may develop.

Local reactions: Inflammatory irritation and pain at the injection site.

Other reactions: Disturbance of taste may be experienced immediately after injection. Headache may develop. In very few cases, convulsion.

Administration of antibiotics including Cefrom-especially if prolonged, may lead to the proliferation of resistant micro-organisms. The patient's condition must therefore be checked at regular intervals. Should a secondary infection occur, appropriate measures must be taken.