Castleman's disease other diagnostic studies

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Castleman's disease Microchapters

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Castleman's disease from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]

Overview

Biopsy

  • Lymph node biopsy is used as a differentiating tool in the diagnosis of Castleman's disease. It is used to differentiate Castleman's from lymphoma.
  • Variants of Castleman's disease can also be differentiated using biopsy.
Micrograph of Castleman's disease, hyaline vascular variant, exhibiting the characteristically expanded mantle zone and a radially penetrating sclerotic blood vessel ("lollipop" sign). H&E stain.
Intermediate magnification micrograph of Castleman disease showing the characteristic expansion of the mantle zone, known as "onion skinning". H&E stain.

References

de:Morbus Castleman

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