|IUPAC name||(8E,10E,12Z)-octadeca-8,10,12-trienoic acid|
|Other names||alpha-calendic acid, 8E,10E,12Z-octadecatrienoic acid, trans-8-trans-10-cis-12-octadecatrienoic acid|
3D model (JSmol)
|ECHA InfoCard||Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).|
|Molar mass||278.43 g/mol|
|Except where noted otherwise, data are given for|
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references
Calendic acid (sometimes α-Calendic acid) is an unsaturated fatty acid, named for the pot marigold (genus Calendula), from which it is obtained. It is chemically similar to the conjugated linoleic acids; laboratory work suggests it may have similar health benefits.
Calendic acid is an omega-6 fatty acid. though not usually listed with this group. Calendic acid (8t,10t,12c-18:3) is synthesised in Calendula officinalis from linoleate (9c,12c-18:2) by an unusual Δ12-oleate desaturase (a FAD 2 variant) that converts the cis-double bond in position 9 to a trans,trans-conjugated double bond system (8t,10t). An all-trans beta isomer has been described.
Calendic acid is the fatty acid responsible for the reduction in feed intake and improved feed utilization in mice when calendular oil is added to the feedstuff, as demonstrated by the comparative experiments in the examples using corn oil.
In vitro, β-calendic acid shows anti-cancer activity against human colon cancer cells.
- Yasui Y, Hosokawa M, Kohno H, Tanaka T, Miyashita K. "Growth inhibition and apoptosis induction by all-trans-conjugated linolenic acids on human colon cancer cells". Anticancer Res. 26 (3A): 1855–60. PMID 16827117.
- Kinney, Tony. "Metabolism in Plants to Produce Healthier Food Oils" (PDF). Retrieved 2007-01-11.
- Christie, William W. "Fatty Acids: Polyunsaturated with other than Methylene-Interrupted Double Bonds". Retrieved 2007-01-11.
- Cyberlipid. "Polyenoic Fatty Acids". Retrieved 2007-01-11.
- Powder formulation comprising conjugated octadecapolyenic acids. Retrieved on 11 January 2007.