Cyclic AMP-responsive element-binding protein 5 is a protein that in humans is encoded by the CREB5gene.[1][2][3]
The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]
References
↑Zu YL, Maekawa T, Nomura N, Nakata T, Ishii S (Oct 1993). "Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter TPA". Oncogene. 8 (10): 2749–58. PMID8378084.
↑Nomura N, Zu YL, Maekawa T, Tabata S, Akiyama T, Ishii S (Mar 1993). "Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1". J Biol Chem. 268 (6): 4259–66. PMID8440710.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID12853948.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID11329013.
<Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID9847074.
