Cell surface transmembrane glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1gene.[1][2][3] CD200R1 is expressed on the surface of myeloid cells[4] and CD4+ T cells.[5] It interacts with CD200 transmembrane glycoprotein that can be expressed on variety of cells including neurons,[6] epithelial cells,[7] endothelial cells,[8] fibroblasts,[9] and lymphoid cells.[10]
CD200R1 activation regulates the expression of pro-inflammatory molecules such as tumor necrosis factor (TNF-alpha),[11] interferons, and inducible nitric oxide synthase (iNOS).[12]
This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants.[3]
References
↑Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (August 2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. doi:10.1016/S1074-7613(00)00023-6. PMID10981966.
↑Dick AD, Broderick C, Forrester JV, Wright GJ (January 2001). "Distribution of OX2 antigen and OX2 receptor within retina". Investigative Ophthalmology & Visual Science. 42 (1): 170–6. PMID11133863.
↑Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (August 2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. PMID10981966.
↑Rosenblum MD, Olasz EB, Yancey KB, Woodliff JE, Lazarova Z, Gerber KA, Truitt RL (November 2004). "Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance?". The Journal of Investigative Dermatology. 123 (5): 880–7. doi:10.1111/j.0022-202X.2004.23461.x. PMID15482475.
↑Gentry M, Bodo J, Durkin L, Hsi ED (February 2017). "Performance of a Commercially Available MAL Antibody in the Diagnosis of Primary Mediastinal Large B-Cell Lymphoma". The American Journal of Surgical Pathology. 41 (2): 189–194. doi:10.1097/PAS.0000000000000771. PMID27879516.
↑Carter DA, Dick AD (June 2004). "CD200 maintains microglial potential to migrate in adult human retinal explant model". Current Eye Research. 28 (6): 427–36. doi:10.1080/02713680490503778. PMID15512951.
Shiratori I, Yamaguchi M, Suzukawa M, Yamamoto K, Lanier LL, Saito T, Arase H (October 2005). "Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200". Journal of Immunology. 175 (7): 4441–9. doi:10.4049/jimmunol.175.7.4441. PMID16177086.
Cherwinski HM, Murphy CA, Joyce BL, Bigler ME, Song YS, Zurawski SM, Moshrefi MM, Gorman DM, Miller KL, Zhang S, Sedgwick JD, Phillips JH (February 2005). "The CD200 receptor is a novel and potent regulator of murine and human mast cell function". Journal of Immunology. 174 (3): 1348–56. doi:10.4049/jimmunol.174.3.1348. PMID15661892.
Karteris E, Chen J, Randeva HS (April 2004). "Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system". The Journal of Clinical Endocrinology and Metabolism. 89 (4): 1957–62. doi:10.1210/jc.2003-031778. PMID15070969.
Wright GJ, Cherwinski H, Foster-Cuevas M, Brooke G, Puklavec MJ, Bigler M, Song Y, Jenmalm M, Gorman D, McClanahan T, Liu MR, Brown MH, Sedgwick JD, Phillips JH, Barclay AN (September 2003). "Characterization of the CD200 receptor family in mice and humans and their interactions with CD200". Journal of Immunology. 171 (6): 3034–46. doi:10.4049/jimmunol.171.6.3034. PMID12960329.
Vieites JM, de la Torre R, Ortega MA, Montero T, Peco JM, Sánchez-Pozo A, Gil A, Suárez A (June 2003). "Characterization of human cd200 glycoprotein receptor gene located on chromosome 3q12-13". Gene. 311: 99–104. doi:10.1016/S0378-1119(03)00562-6. PMID12853143.
