CCNA1

Cyclin A1
Identifiers
Symbols	CCNA1 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31203
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cyclin A1, also known as CCNA1, is a human gene.

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins.

Further reading

• Hall M, Bates S, Peters G (1995). "Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins". Oncogene. 11 (8): 1581–8. PMID 7478582.CS1 maint: Multiple names: authors list (link)
• Xu M, Sheppard KA, Peng CY; et al. (1994). "Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation". Mol. Cell. Biol. 14 (12): 8420–31. PMID 7969176.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• O'Connor PM, Ferris DK, Pagano M; et al. (1993). "G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently". J. Biol. Chem. 268 (11): 8298–308. PMID 8463339.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sweeney C, Murphy M, Kubelka M; et al. (1996). "A distinct cyclin A is expressed in germ cells in the mouse". Development. 122 (1): 53–64. PMID 8565853.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang R, Morosetti R, Koeffler HP (1997). "Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines". Cancer Res. 57 (5): 913–20. PMID 9041194.CS1 maint: Multiple names: authors list (link)
• Wang H, Shao N, Ding QM; et al. (1997). "BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases". Oncogene. 15 (2): 143–57. doi:10.1038/sj.onc.1201252. PMID 9244350.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu D, Matzuk MM, Sung WK; et al. (1998). "Cyclin A1 is required for meiosis in the male mouse". Nat. Genet. 20 (4): 377–80. doi:10.1038/3855. PMID 9843212.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang R, Müller C, Huynh V; et al. (1999). "Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins". Mol. Cell. Biol. 19 (3): 2400–7. PMID 10022926.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ravnik SE, Wolgemuth DJ (1999). "Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage". Dev. Biol. 207 (2): 408–18. doi:10.1006/dbio.1998.9156. PMID 10068472.
• Yang R, Nakamaki T, Lübbert M; et al. (1999). "Cyclin A1 expression in leukemia and normal hematopoietic cells". Blood. 93 (6): 2067–74. PMID 10068680.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Müller C, Yang R, Beck-von-Peccoz L; et al. (1999). "Cloning of the cyclin A1 genomic structure and characterization of the promoter region. GC boxes are essential for cell cycle-regulated transcription of the cyclin A1 gene". J. Biol. Chem. 274 (16): 11220–8. PMID 10196209.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ruffner H, Jiang W, Craig AG; et al. (1999). "BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site". Mol. Cell. Biol. 19 (7): 4843–54. PMID 10373534.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brown NR, Noble ME, Endicott JA, Johnson LN (2001). "The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases". Nat. Cell Biol. 1 (7): 438–43. doi:10.1038/15674. PMID 10559988.CS1 maint: Multiple names: authors list (link)
• Liu D, Liao C, Wolgemuth DJ (2000). "A role for cyclin A1 in the activation of MPF and G2-M transition during meiosis of male germ cells in mice". Dev. Biol. 224 (2): 388–400. doi:10.1006/dbio.2000.9776. PMID 10926775.CS1 maint: Multiple names: authors list (link)
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Müller-Tidow C, Bornemann C, Diederichs S; et al. (2001). "Analyses of the genomic methylation status of the human cyclin A1 promoter by a novel real-time PCR-based methodology". FEBS Lett. 490 (1–2): 75–8. PMID 11172814.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Simpson JC, Wellenreuther R, Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Müller-Tidow C, Wang W, Idos GE; et al. (2001). "Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function". Blood. 97 (7): 2091–7. PMID 11264176.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)