CCDC181

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VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Coiled-coil domain-containing protein 181 (CCDC181) is a protein that in human is encoded by C1orf114,[1] which is located at the Chromosome 1 at 1q24.2.[1] The accession is Q5T1D7.[1] Researches have recently revealed that CCDC 181 is a microtubule-binding protein that interacts with murine Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia.[2] The disruption of Hook1 may lead to inappropriate function of spermatogenesis. The dysfunction may be related to the abnormal head shape of sperm or distinctive structural changes in flagella in sperm, and could be possible end up in male infertility. An increased rate of my gene has found in the haploid phase of male cell during meiosis, thus it is believed to relate to sperm cell and aid in spermatogenesis.

Expression

It is discovered that a significant high expression of CCDC 181 found on human testis, which is a male reproductive gland. This is related to the study of its encoded protein-CCDC181, which relates to human infertility when in low expression. Also, high expression of protein is found in the olfactory area and cortical subplate. Researchers have studied the expression of CCDC 181 under different conditions. One of the outstanding findings is that under the coexistence of Rho GTP dissociation inhibitor, the expression of CCDC 181 is depressed. Rho GTP dissociation inhibitor has a phenomenal effect on bladder cancer cells, so studies have suggested that CCDC 181 might also be related to bladder cancer.

Homology

Orthologs have been found mainly in eukaryotes, including mammals, birds, reptiles, amphibians and fishes, with the highest identity on the mammalian species.

Genus

species

Common

name

Divergence

from

humans

(MYA)

NCBI

mRNA

accession

Sequence

identity

Sequence similarity Length

(aa)

Homo sapiens Humans -- NM_001300968 -- -- 508
Odobenus rosmarus divergens Walrus 96 XP_012420860 86% 93% 507
Physeter catodon Sperm whale 96 XP_007102112 84% 91% 509
Balaenoptera acutorostrata scammoni Minke whale 96 XP_007172548 84% 90% 509
Ictidomys tridecemlineatus Thirteen-lined ground squirrel 90 XP_021578354 81% 90% 507
Octodon degus Degu 90 XP_023564408 80% 89% 537
Rousettus aegyptiacus Egyptian fruit bat 96 XP_016004092 78% 88% 505
Pteropus vampyrus Large flying fox 96 XP_023393329 78% 89% 522
Condylura cristata star-nosed mole 96 XP_004688522 78% 87% 508
Mustela putorius furo Ferret 96 XP_004756715 69% 78% 459
Nestor notabilis Kea 312 XP_010014066 56% 72% 498
Pelodiscus sinensis Chinese softshell turtle 312 XP_006112275 55% 73% 512
Sorex araneus shrew 96 XP_012789334 55% 71% 502
Chelonia mydas Green sea turtle 312 XP_007061692 54% 72% 517
Xenopus tropicalis western clawed frog 352 XP_012813116 42% 61% 471
Lonchura striata domestica society finch 312 XP_021404557 40% 61% 488
Nanorana parkeri High Himalaya frog 352 XP_018423291 36% 56% 334
Scleropages formosus Asian arowana 435 XP_018603557 35% 55% 389
Hippocampus comes Tiger tail seahorse 435 XP_019735712 29% 44% 439
  1. 1.0 1.1 1.2 "Homo sapiens coiled-coil domain containing 181 (CCDC181), transcript v - Nucleotide - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2018-05-01.
  2. Schwarz T, Prieler B, Schmid JA, Grzmil P, Neesen J (May 2017). "Ccdc181 is a microtubule-binding protein that interacts with Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia". European Journal of Cell Biology. 96 (3): 276–288. doi:10.1016/j.ejcb.2017.02.003. PMC 5496667. PMID 28283191.

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