CARD8

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Caspase recruitment domain family, member 8
Identifiers
Symbols CARD8 ; CARDINAL; DACAR; DKFZp779L0366; KIAA0955; MGC57162; NDPP1; TUCAN
External IDs OMIM: 609051 HomoloGene75034
RNA expression pattern
PBB GE CARD8 204950 at tn.png
More reference expression data
Orthologs

| | bgcolor="#C3FDB8" | Human | bgcolor="#C3FDB8" | Mouse |-

    | bgcolor="#C3FDB8" | Entrez 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 22900
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| na

|-

     | bgcolor="#C3FDB8" | Ensembl
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSG00000105483
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| na

|-

    | bgcolor="#C3FDB8" | Uniprot
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q9Y2G2
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| na

|-

    | bgcolor="#C3FDB8" | Refseq
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" | NM_014959 (mRNA)
NP_055774 (protein)
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" |na (mRNA)
na (protein)

|-

    | bgcolor="#C3FDB8" | Location
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 19: 53.4 - 53.45 Mb 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| na

|-

|-

    | bgcolor="#C3FDB8" | Pubmed search 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [1]
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| na
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Caspase recruitment domain family, member 8, also known as CARD8, is a human gene.[1]

Caspase recruitment domain (CARD)-containing proteins, such as CARD8, are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB; see MIM 164011) in the context of apoptosis or inflammation, respectively (Bouchier-Hayes et al., 2001).[supplied by OMIM][1]

References

  1. 1.0 1.1 "Entrez Gene: CARD8 caspase recruitment domain family, member 8".

Further reading

  • Fontalba A, Martinez-Taboada V, Gutierrez O; et al. (2007). "Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity". J. Immunol. 179 (7): 4867–73. PMID 17878386.
  • Franke A, Rosenstiel P, Balschun T; et al. (2007). "No association between the TUCAN (CARD8) Cys10Stop mutation and inflammatory bowel disease in a large retrospective German and a clinically well-characterized Norwegian sample". Gastroenterology. 132 (5): 2080–1. doi:10.1053/j.gastro.2007.03.087. PMID 17484912.
  • McGovern DP, Butler H, Ahmad T; et al. (2006). "TUCAN (CARD8) genetic variants and inflammatory bowel disease". Gastroenterology. 131 (4): 1190–6. doi:10.1053/j.gastro.2006.08.008. PMID 17030188.
  • Checinska A, Giaccone G, Hoogeland BS; et al. (2006). "TUCAN/CARDINAL/CARD8 and apoptosis resistance in non-small cell lung cancer cells". BMC Cancer. 6: 166. doi:10.1186/1471-2407-6-166. PMID 16796750.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Agostini L, Martinon F, Burns K; et al. (2004). "NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder". Immunity. 20 (3): 319–25. PMID 15030775.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Stilo R, Leonardi A, Formisano L; et al. (2002). "TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation". FEBS Lett. 521 (1–3): 165–9. PMID 12067710.
  • Zhang H, Fu W (2002). "NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-kappaB activation". Int. J. Oncol. 20 (5): 1035–40. PMID 11956601.
  • Razmara M, Srinivasula SM, Wang L; et al. (2002). "CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis". J. Biol. Chem. 277 (16): 13952–8. doi:10.1074/jbc.M107811200. PMID 11821383.
  • Bouchier-Hayes L, Conroy H, Egan H; et al. (2001). "CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways". J. Biol. Chem. 276 (47): 44069–77. doi:10.1074/jbc.M107373200. PMID 11551959.
  • Pathan N, Marusawa H, Krajewska M; et al. (2001). "TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer". J. Biol. Chem. 276 (34): 32220–9. doi:10.1074/jbc.M100433200. PMID 11408476.
  • Nagase T, Ishikawa K, Suyama M; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. PMID 10231032.

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