C4 glomerulopathy history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Ali Poyan Mehr, M.D. [2]; Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3]

Overview

The most common symptoms of C4 glomerulopathy include hematuria, proteinuria, and hypertension.

History and Symptoms

History

Patients with C4 glomerulopathy may have a positive history of[1]:

  • Hypertension
  • Nephrotic Syndrome
  • Nephritic Syndrome
  • Autoimmune disorder

Common Symptoms

Common symptoms of C4 glomerulopathy include[2]:

  • Proteinuria
  • Hematuria
  • Edema
  • Malaise
  • Fatigue
  • Hypertension

References

  1. Zhang Y, Meyer NC, Fervenza FC, Lau W, Keenan A, Cara-Fuentes G; et al. (2017). "C4 Nephritic Factors in C3 Glomerulopathy: A Case Series". Am J Kidney Dis. 70 (6): 834–843. doi:10.1053/j.ajkd.2017.07.004. PMC 5701858. PMID 28838767.
  2. Sethi S, Sullivan A, Smith RJ (2014). "C4 dense-deposit disease". N Engl J Med. 370 (8): 784–6. doi:10.1056/NEJMc1309449. PMID 24552345.

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