C11orf52 is located on chromosome 11 at 11q23.1, starting at 111908620 and ending at 112064278.[1] C11orf52 spans 155658 base pairs and is orientated on the positive strand. Gene C11orf52 has a molecular weight of 14kDa and is a protein coding gene of 7,995 bp containing four exons. The coding region is made up of 1,168 bp.[2]
Gene neighborhood
Genes HSPB2, CRYAB, OLAT, and PPIHP1 neighbor C11orf52 on chromosome 11.
There is only one variant of C11orf52 RNA. The mRNA sequence is 1,140 base pairs long.[2] There is an upstream stop codon located at nucleotides 65 – 67. The 23rd amino acid varies between threonine and arginine.[2]
Protein
The 123 amino acid chain is a domain of unknown function.[5] It has a molecular weight of 13,9 kDal and a predicted Isoelectric Point of 9.74 [2] C11orf52 is predicted to be targeted to the nucleus.
There are no isoforms of the protein encoded by C11orf52.
The LYS19-22 region is an external domain of the protein structure.[2]
Homology
Orthologs
There is only one member of the C11orf52 gene family and no splice isoforms can be found going back to Geospiza fortis - the most distantly related to Homo Sapiens C11orf52 sequence. Gene duplication first occurred approximately 324.5 million years ago in reptiles and birds. There are no paralogs for the C11orf52 gene.
Unusual DNA methylation in the C11orf52 gene in some children can be attributed to prenatal smoke exposure.[6]
C11orf52 may also play a role in lung cancer. C11orf52 is expressed in the lungs and has been associated with increased phosphorylation in cell lung cancer tumors. There is evidence that phosphorylation mechanisms exist which enhance proteins and pathways which should have inhibited phosphorylation in order to prevent extreme proliferation. C11orf52 is one gene where the phosphorylation is significantly different between the cancerous cells and normal tissue.[7]
Further reading
Varjosalo M, Keskitalo S, Van Drogen A, Nurkkala H, Vichalkovski A, Aebersold R, Gstaiger M (April 2013). "The protein interaction landscape of the human CMGC kinase group". Cell Reports. 3 (4): 1306–20. doi:10.1016/j.celrep.2013.03.027. PMID23602568.
↑Nielsen CH, Larsen A, Nielsen AL (February 2016). "DNA methylation alterations in response to prenatal exposure of maternal cigarette smoking: A persistent epigenetic impact on health from maternal lifestyle?". Archives of Toxicology. 90 (2): 231–45. doi:10.1007/s00204-014-1426-0. PMID25480659.
↑Wu CJ, Cai T, Rikova K, Merberg D, Kasif S, Steffen M (November 2009). "A predictive phosphorylation signature of lung cancer". PLOS One. 4 (11): e7994. doi:10.1371/journal.pone.0007994. PMID19946374.
