C-C motif chemokine ligand 24

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
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PubMed search	n/a	n/a
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View/Edit Human

C-C motif chemokine ligand 24 is a protein that in humans is encoded by the CCL24 gene.

Function

This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. [provided by RefSeq, Jul 2008].

Further reading

• Papadopoulos NG, Papi A, Meyer J, Stanciu LA, Salvi S, Holgate ST, Johnston SL (July 2001). "Rhinovirus infection up-regulates eotaxin and eotaxin-2 expression in bronchial epithelial cells". Clin. Exp. Allergy. 31 (7): 1060–6. PMID 11467997.
• Tachimoto H, Kikuchi M, Hudson SA, Bickel CA, Hamilton RG, Bochner BS (June 2002). "Eotaxin-2 alters eosinophil integrin function via mitogen-activated protein kinases". Am. J. Respir. Cell Mol. Biol. 26 (6): 645–9. doi:10.1165/ajrcmb.26.6.4741. PMID 12034562.
• Badewa AP, Hudson CE, Heiman AS (September 2002). "Regulatory effects of eotaxin, eotaxin-2, and eotaxin-3 on eosinophil degranulation and superoxide anion generation". Exp. Biol. Med. (Maywood). 227 (8): 645–51. PMID 12192108.
• Menzies-Gow A, Ying S, Sabroe I, Stubbs VL, Soler D, Williams TJ, Kay AB (September 2002). "Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers". J. Immunol. 169 (5): 2712–8. PMID 12193745.
• Chae SC, Lee YC, Park YR, Shin JS, Song JH, Oh GJ, Hong ST, Pae HO, Choi BM, Chung HT (July 2004). "Analysis of the polymorphisms in eotaxin gene family and their association with asthma, IgE, and eosinophil". Biochem. Biophys. Res. Commun. 320 (1): 131–7. doi:10.1016/j.bbrc.2004.05.136. PMID 15207712.
• Chae SC, Park YR, Oh GJ, Lee JH, Chung HT (January 2005). "The suggestive association of eotaxin-2 and eotaxin-3 gene polymorphisms in Korean population with allergic rhinitis". Immunogenetics. 56 (10): 760–4. doi:10.1007/s00251-004-0746-2. PMID 15580493.
• Min JW, Lee JH, Park CS, Chang HS, Rhim TY, Park SW, Jang AS, Shin HD (2005). "Association of eotaxin-2 gene polymorphisms with plasma eotaxin-2 concentration". J. Hum. Genet. 50 (3): 118–23. doi:10.1007/s10038-005-0230-3. PMID 15744457.
• Min JW, Jang AS, Park SM, Lee SH, Lee JH, Park SW, Park CS (November 2005). "Comparison of plasma eotaxin family level in aspirin-induced and aspirin-tolerant asthma patients". Chest. 128 (5): 3127–32. doi:10.1378/chest.128.5.3127. PMID 16304252.
• Park YR, Choi SC, Lee ST, Kim KS, Chae SC, Chung HT (December 2005). "The association of eotaxin-2 and eotaxin-3 gene polymorphisms in a Korean population with ulcerative colitis". Exp. Mol. Med. 37 (6): 553–8. doi:10.1038/emm.2005.68. PMID 16391516.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.