Brushfield spots are small white or grayish/brown spots on the periphery of the iris in the human eye due to aggregation of a normal iris element (connective tissue). These spots are normal in children but are also a feature of Down syndrome. They occur in 35-78% of newborn infants with Down syndrome. They are much more likely to occur in Down syndrome children of the Caucasian race than children of Asian heritage. Brushfield spots are named after the physician, Thomas Brushfield, who first described them in 1924.
- Sanez, R.B. (January 1999), "Primary care of infants and young children with down syndrome.", American Family Physician, 59 (2)
- Kim, J.H.; et al. (November 2002), "Characteristic ocular findings in Asian children with Down syndrome.", Nature, 16 (6)