Brucellosis medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Danitza Lukac Vishal Devarkonda, M.B.B.S[3]


The mainstay of therapy for brucellosis is antimicrobial therapy. The preferred regimen for uncomplicated brucellosis is a combination of Doxycycline and streptomycin. Rifampicin is the drug of choice for brucellosis in pregnancy. For children less than 8 years of age, the preferred regimen is either gentamycin or a combination of trimethoprim-sulfamethoxazole and streptomycin.[1]

Medical Therapy

The mainstay of therapy for brucellosis is antimicrobial therapy:[2][3][4][5][6][7]

  • Doxycycline and streptomycin are used in combination for 2-3 weeks to prevent recurring infection.
  • Depending on the timing of treatment and severity of illness, recovery may take a few weeks to several months.
  • The use of more than one antibiotic is needed for several weeks, due to the fact that the bacteria incubates within cells.
Antimicrobial therapy for Brucellosis
Uncomplicated brucellosis in adults and children ≥8yrs of age
Complications of brucellosis
  • Spondylitis
  • Neurobrucellosis
  • Brucella endocarditis
.For children < 8 yrs of age
.Post-exposure prophylaxis
  • Preferred regimen (1): Doxycycline 100mg PO bid for at least 3 weeks
  • Preferred regimen (2): TMP/SMZ 160 mg/800mg PO bid for at least 3 weeks


  1. Brucellosis. CDC. Accessed on February 5, 2016
  2. "CDC".
  3. Brucellosis "Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo"Harrison's Principles of Internal Medicine, 19e Accessed on December 9th, 2017
  4. Young EJ (1995). "Brucellosis: current epidemiology, diagnosis, and management."Curr Clin Top Infect Dis15: 115–28. PMID 7546364
  5. Aygen B, Doganay M, Sumerkan B, et al. Clinical manifestations, complications and treatment of brucellosis: a retrospective evaluation of 480 patients. Med Malad Infect 2002; 32:485.
  6. Herrick JA, Lederman RJ, Sullivan B, et al. Brucella arteritis: clinical manifestations, treatment, and prognosis. Lancet Infect Dis 2014; 14:520.
  7. Ariza J, Bosilkovski M, Cascio A, Colmenero JD, Corbel MJ, Falagas ME; et al. (2007). "Perspectives for the treatment of brucellosis in the 21st century: the Ioannina recommendations."PLoS Med4 (12): e317. 

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