Brimonidine drug interactions

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


List of drug interactions

CNS depressants/beta-blockers

Tricyclic antidepressants







CNS depressants/beta-blockers

Although specific drug interaction studies have not been conducted with Brimonidine tartrate ophthalmic solution 0.2%, the possibility of an additive or potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, or anesthetics) should be considered. Alpha-agonists, as a class, may reduce pulse and blood pressure. Caution in using concomitant drugs such as beta-blockers (ophthalmic and systemic), antihypertensives and/or cardiac glycosides is advised. Return to top

Tricyclic antidepressants

Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine. It is not known whether the concurrent use of these agents with Brimonidine tartrate ophthalmic solution 0.2% in humans can lead to resulting interference with the IOP lowering effect. No data on the level of circulating catecholamines after Brimonidine tartrate ophthalmic solution 0.2% are available. Caution, however, is advised in patients taking tricyclic antidepressants which can affect the metabolism and uptake of circulating amines. Return to top

Alphagan-P (Brimonidine): Complete List of Drug Interactions

Major Interactions

Moderate Interactions

Minor Interactions



Adapted from the FDA Package Insert.


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