Biliary cystadenoma and cystadenocarcinoma natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]
Overview
Common complication of biliary cystadenoma include neoplastic transformation to biliary cystadenocarcinoma. Biliary cystadenoma with mesenchymal stroma is associated with most favorable prognosis.[1]
Complications
- In fact, even if the cystadenoma is a benign neoplasm, it has a high rate of recurrence and a potential for neoplastic transformation.
- Malignant transformation rate can be as high as 30%.[2]
Prognosis
Although biliary cystadenomas are benign tumors, they may recur after excision and have potential to develop into biliary cystadenocarcinomas.[3]
Biliary cystadenoma
- The prognosis of completely removed billiary cystadenomas is excellent, recurrence is rare.[4]
- Cystadenomas with mesenchymal stroma are considered premalignant with a good prognosis while those without are known to transform to malignancy more often with a poor prognosis.[1]
Biliary cystadenocarcinoma
- When treated with radical excision biliary cystadenocarcinomas have good prognosis, particularly those with mesenchymal stroma, unless the tumor invades the adjacent liver tissue or neighboring organs, or metastases are present.[4]
- Biliary cystadenocarcinomas in men which are not associated with mesenchymal stroma have worse prognosis, even after complete excision.[4]
References
- ↑ 1.0 1.1 Ahanatha Pillai, Sastha; Velayutham, Vimalraj; Perumal, Senthilkumar; Ulagendra Perumal, Srinivasan; Lakshmanan, Anand; Ramaswami, Sukumar; Ramasamy, Ravi; Sathyanesan, Jeswanth; Palaniappan, Ravichandran; Rajagopal, Surendran (2012). "Biliary Cystadenomas: A Case for Complete Resection". HPB Surgery. 2012: 1–6. doi:10.1155/2012/501705. ISSN 0894-8569.
- ↑ Ramacciato, Giovanni; Nigri, Giuseppe R; D'Angelo, Francesco; Aurello, Paolo; Bellagamba, Riccardo; Colarossi, Cristina; Pilozzi, Emanuela; Del Gaudio, Massimo (2006). World Journal of Surgical Oncology. 4 (1): 76. doi:10.1186/1477-7819-4-76. ISSN 1477-7819. Missing or empty
|title=(help) - ↑ Biliary cystadenoma.Dr Yuranga Weerakkody and Radswiki et al.Radiopaedia.org 2015. http://radiopaedia.org/articles/biliary-cystadenoma
- ↑ 4.0 4.1 4.2 Chandrasekar, G. (2015), Biliary Cystadenoma of Liver. (PDF), Chennai: Stanley Medical Journal, p. 37-42, retrieved December 10, 2015