Beclamide

Beclamide

File:Beclamide.svg
Gene therapy
Clinical data
Routes of administration	Oral
ATC code	N03AX30 (WHO)
Physiological data
Legal status
Pharmacokinetic data
Identifiers
IUPAC name N-benzyl-3-chloropropionamide
CAS Number	501-68-8
PubChem Template:Abbreviation	10391
Chemical and physical data

Beclamide (marketed as Chloracon, Hibicon, Posedrine, Nydrane, Seclar, and other names) is a propionate and was used as a sedative and as an anticonvulsant.

Side effects are uncommon but include stomach pain, nervousness, giddiness, skin rash and leukopenia. It is counter-indicated in breast feeding as it is passed in the milk.

Administration is oral, though it has an unpleasant taste. It is quickly absorbed and elimination is renal and complete within 48 hours.

It was studied in the 1950s for its anticonvulsant properties, as a treatment for generalised tonic-clonic seizures. It was not effective for absence seizures. It is no longer used as an AED. Interest in the drug resumed in the 1990s for its psychiatric properties as an adjunct in the treatment of schizophrenia.

References

• The Medical Treatment of Epilepsy by Stanley R Resor. Published by Marcel Dekker (1991). ISBN 0-8247-8549-5.
• Beclamide (in French)

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