Basal optic nucleus of Meynert

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Brain: Basal optic nucleus of Meynert
Latin n. basalis telencephali
NeuroNames hier-257
MeSH Basal+nucleus+of+Meynert
Dorlands/Elsevier n_11/12580484

The basal nucleus of Meynert (NBM) is a group of nerve cells in the substantia innominata of the basal forebrain, in the lateral part of the tuber cinereum, that has wide projections to the neocortex and is rich in acetylcholine and choline acetyltransferase.

Clinical significance

In Parkinson and Alzheimer diseases the nucleus undergoes degeneration. A decrease in acetylcholine production is seen in Alzheimer's disease, Lewy body dementia and some Parkinson Disease patients showing abnormal brain function, leading to a general decrease of mental capacity and learning.

Most pharmacological treatments of dementia focus on compensating for a faltering NBM function through artificially increasing acetylcholine levels.

Cholinergic neurons/cell bodies

The primary concentration of cholinergic neurons/cell bodies that project to the neocortex are in the basal nucleus of Meynert which is located in the substantia innominata of the anterior perforated substance.

External links


This article was originally based on an entry from a public domain edition of Gray's Anatomy. As such, some of the information contained herein may be outdated. Please edit the article if this is the case, and feel free to remove this notice when it is no longer relevant.


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