BRD8

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Bromodomain-containing protein 8 is a protein that in humans is encoded by the BRD8 gene.[1][2][3]

The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct isoforms have been identified.[3]

Interactions

BRD8 has been shown to interact with Thyroid hormone receptor beta[2] and Retinoid X receptor alpha.[4]

References

  1. Nielsen MS, Petersen CM, Gliemann J, Madsen P (Jun 1996). "Cloning and sequencing of a human cDNA encoding a putative transcription factor containing a bromodomain". Biochim Biophys Acta. 1306 (1): 14–6. doi:10.1016/0167-4781(95)00239-1. PMID 8611617.
  2. 2.0 2.1 Monden T, Wondisford FE, Hollenberg AN (Dec 1997). "Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein". J Biol Chem. 272 (47): 29834–41. doi:10.1074/jbc.272.47.29834. PMID 9368056.
  3. 3.0 3.1 "Entrez Gene: BRD8 bromodomain containing 8".
  4. Monden, T; Kishi M; Hosoya T; Satoh T; Wondisford F E; Hollenberg A N; Yamada M; Mori M (Oct 1999). "p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers". Mol. Endocrinol. UNITED STATES. 13 (10): 1695–703. doi:10.1210/me.13.10.1695. ISSN 0888-8809. PMID 10517671.

External links

Further reading




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