Azelnidipine

Azelnidipine
Gene therapy
Clinical data
Routes of; administration	Oral
Physiological data
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Identifiers
	IUPAC name O3-[1-[di(phenyl)methyl]azetidin-3-yl] O5-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;
CAS Number	123524-52-7;
PubChem Template:Abbreviation	65948;
Chemical and physical data
Formula	C33H34N4O6
Molar mass	582.64 g/mol
3D model (JSmol)	Interactive image;
	SMILES CC1=C(C(C(=C(N1)N)C(=O)OC2CN(C2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5) [N+](=O)[O-])C(=O)OC(C)C;

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Azelnidipine (INN; marketed under the brand name Calblock) is a dihydropyridine calcium channel blocker.

Unlike nicardipine, it has a gradual onset and has a long-lasting hypotensive effect, with little increase in heart rate.^[1]

References

↑ Oizumi K, Nishino H, Koike H, Sada T, Miyamoto M, Kimura T (1989). "Antihypertensive effects of CS-905, a novel dihydropyridine Ca++ channel blocker". Jpn. J. Pharmacol. 51 (1): 57–64. PMID 2810942. Unknown parameter |month= ignored (help)

Gene therapy

Clinical data
Routes of administration	Oral
Physiological data
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Identifiers
IUPAC name O3-[1-[di(phenyl)methyl]azetidin-3-yl] O5-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS Number	123524-52-7
PubChem Template:Abbreviation	65948
Chemical and physical data
Formula	C₃₃H₃₄N₄O₆
Molar mass	582.64 g/mol
3D model (JSmol)	Interactive image
SMILES CC1=C(C(C(=C(N1)N)C(=O)OC2CN(C2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5) [N+](=O)[O-])C(=O)OC(C)C