Autophagy-related protein 13

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Autophagy-related protein 13 also known as ATG13 is a protein that in humans is encoded by the KIAA0652 gene.[1]

ATG13 is an autophagy factor required for phagosome formation. ATG13 is a target of the TOR kinase signaling pathway that regulates autophagy through phosphorylation of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex.[2][3][4]

References

  1. "Entrez Gene: KIAA0652".
  2. Mercer CA, Kaliappan A, Dennis PB (July 2009). "A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy". Autophagy. 5 (5): 649–62. doi:10.4161/auto.5.5.8249. PMID 19287211.
  3. Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, Guan JL, Oshiro N, Mizushima N (April 2009). "Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy". Mol. Biol. Cell. 20 (7): 1981–91. doi:10.1091/mbc.E08-12-1248. PMC 2663915. PMID 19211835.
  4. Chan EY, Longatti A, McKnight NC, Tooze SA (January 2009). "Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism". Mol. Cell. Biol. 29 (1): 157–71. doi:10.1128/MCB.01082-08. PMC 2612494. PMID 18936157.

External links

Further reading