Atrioventricular septal defect pathophysiology

Jump to navigation Jump to search

Atrioventricular septal defect Microchapters


Patient Information





Differentiating Atrioventricular septal defect from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis


History and Symptoms

Physical Examination

Laboratory Findings


Chest X Ray




Cardiac Catheterization


Medical Therapy




Cost-Effectiveness of Therapy

Future or Investigational Therapies

Atrioventricular septal defect pathophysiology On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Atrioventricular septal defect pathophysiology

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical

US National Guidelines Clearinghouse

NICE Guidance

FDA on Atrioventricular septal defect pathophysiology

CDC on Atrioventricular septal defect pathophysiology

Atrioventricular septal defect pathophysiology in the news

Blogs on Atrioventricular septal defect pathophysiology

Directions to Hospitals Treating Type page name here

Risk calculators and risk factors for Atrioventricular septal defect pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]



There are many underlying mechanisms resulting in atrioventricular septal defect depends largely on the nature of interaction of blood flow between the right and left sides of the heart. Factors influencing the severity include: ventricular imbalance, the size of AV septal defects, AVV competence, the degree of right-sided or left-sided outflow obstruction, pulmonary vascular resistance, the amount of atrioventricular valve regurgitation and the magnitude of blood flow through the ventricular septum. The determination of the degree of left-to-right shunting can be done examining the size of the communication and the relative compliance of the two atria and ventricles.

Newborns may experience little left-to-right shunting as a result of a less compliant right ventricle and a relatively high PVR. Larger defects may result in mixing of a common or near-common atrium and create components of right-to-left shunting. The propensity for left-to-right shunting increaes with age as a result of a decrease in PVR and right ventricle compliance increase.

Asymptomatic patients often have little atrioventricular valve regurgitation and higher pulmonary vascular resistance. Pulmonary overcirculation is often an earmark of an AVSD.

Infants may present with congestive heart failure, tachypnea, excessive sweating, failure to thrive, extremis with acidosis, severe hypoplasia of left-sided structures with ductal-dependent systemic circulation, and severe cyanosis in right-sided structures with ductal-dependent systemic circulation. If an AVSD is coupled with an VSD, there is a high risk of pulmonary vascular disease.

Older patients may present progressive right ventricle enlargement and pulmonary vascular engorgement.The degree of regurgitation through the anterior mitral valve leaflet cleft can result in a left ventricular outflow tract obstruction of a coarctation of the aorta.


Gross Pathology

Picture below shows atrial septal defect in atrioventricular septal defect

Picture below shows complete atrioventricular septal defect.


Template:WH Template:WS CME Category::Cardiology