Aspergillosis laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]; Yazan Daaboul, M.D.; Serge Korjian M.D.


PCR is the method of choice for the diagnosis of aspergillosis. A single negative PCR result is sufficient to rule out aspergillosis, whereas two positive test results are required to confirm the diagnosis. Laboratory findings consistent with the diagnosis of aspergillosis include positive aspergillus antibody test, positive galactomannan test, elevated concentration of IgE immunoglobulin, and positive culture from sputum or bronchoalveolar lavage.[1][2][3]

Polymerase Chain Reaction

  • PCR is the method of choice for the diagnosis of Aspergillosis.
  • A single negative PCR result is sufficient to rule out a diagnosis of a probable invasive aspergillosis.[4]
  • While, two positive test results are required to confirm a diagnosis of aspergillosis.

Other Laboratory Findings

Complete Blood Count




  • Positive culture and staining from sputum or from bronchoalveolar lavage (BAL)
  • Culture can be performed on a variety of sterile specimens. Aspergillus spp. typically appear as rapidly growing molds that are visible 1-3 days following incubation.
  • Patients with invasive aspergillosis may have negative cultures.


  1. Aspergillosis. Wikipedia (2015) Accessed on February, 8 2016
  2. Cuenca-Estrella M, Bassetti M, Lass-Flörl C, Rácil Z, Richardson M, Rogers TR (2011). "Detection and investigation of invasive mould disease". J Antimicrob Chemother. 66 Suppl 1: i15–24. doi:10.1093/jac/dkq438. PMID 21177400.
  3. Kradin RL, Mark EJ (2008). "The pathology of pulmonary disorders due to Aspergillus spp". Arch Pathol Lab Med. 132 (4): 606–14. doi:10.1043/1543-2165(2008)132[606:TPOPDD]2.0.CO;2. PMID 18384212.
  4. Mengoli C, Cruciani M, Barnes RA, Loeffler J, Donnelly JP (2009). "Use of PCR for diagnosis of invasive aspergillosis: systematic review and meta-analysis". Lancet Infect Dis. 9 (2): 89–96. doi:10.1016/S1473-3099(09)70019-2. PMID 19179225.