Arachidonate 8-lipoxygenase

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In enzymology, an arachidonate 8-lipoxygenase (EC 1.13.11.40) is an enzyme that catalyzes the chemical reaction

arachidonate + O2 (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate

Thus, the two substrates of this enzyme are arachidonate and O2, whereas its product is (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is arachidonate:oxygen 8-oxidoreductase. Other names in common use include 8-lipoxygenase, and 8(R)-lipoxygenase. This enzyme participates in arachidonic acid metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2FNQ.

References

  • IUBMB entry for 1.13.11.40
  • BRENDA references for 1.13.11.40 (Recommended.)
  • PubMed references for 1.13.11.40
  • PubMed Central references for 1.13.11.40
  • Google Scholar references for 1.13.11.40
  • Bundy GL, Nidy EG, Epps DE, Mizsak SA, Wnuk RJ (1986). "Discovery of an arachidonic acid C-8 lipoxygenase in the gorgonian coral Pseudoplexaura porosa". J. Biol. Chem. 261: 747&ndash, 51. PMID 2867091.

External links

The CAS registry number for this enzyme class is 100900-72-9.

Gene Ontology (GO) codes


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